The osmotic rupture hypothesis of intracellular freezing injury
A hypothesis of the nature of intracellular ice formation is proposed in which the osmotically driven water efflux that occurs in cells during freezing (caused by the increased osmotic pressure of the extracellular solution in the presence of ice) is viewed as the agent responsible for producing a r...
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| Veröffentlicht in: | Biophysical journal 1994-02, Vol.66 (2), p.532-541 |
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| container_title | Biophysical journal |
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| creator | Muldrew, K. McGann, L.E. |
| description | A hypothesis of the nature of intracellular ice formation is proposed in which the osmotically driven water efflux that occurs in cells during freezing (caused by the increased osmotic pressure of the extracellular solution in the presence of ice) is viewed as the agent responsible for producing a rupture of the plasma membrane, thus allowing extracellular ice to propagate into the cytoplasm. This hypothesis is developed into a mathematical framework and the forces that are present during freezing are compared to the forces which are required to rupture membranes in circumstances unrelated to low temperatures. The theory is then applied to systems which have been previously studied to test implications of the theory on the nature of intracellular ice formation. The pressure that develops during freezing due to water flux is found to be sufficient to cause a rupture of the plasma membrane and the theory gives an accurate description of the phenomenology of intracellular ice formation. |
| doi_str_mv | 10.1016/S0006-3495(94)80806-9 |
| format | Article |
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This hypothesis is developed into a mathematical framework and the forces that are present during freezing are compared to the forces which are required to rupture membranes in circumstances unrelated to low temperatures. The theory is then applied to systems which have been previously studied to test implications of the theory on the nature of intracellular ice formation. The pressure that develops during freezing due to water flux is found to be sufficient to cause a rupture of the plasma membrane and the theory gives an accurate description of the phenomenology of intracellular ice formation.</description><identifier>ISSN: 0006-3495</identifier><identifier>EISSN: 1542-0086</identifier><identifier>DOI: 10.1016/S0006-3495(94)80806-9</identifier><identifier>PMID: 8161706</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Biophysical Phenomena ; Biophysics ; Cell Line ; Cell Membrane - metabolism ; Cricetinae ; Cricetulus ; Female ; Freezing ; Ice ; Intracellular Fluid - chemistry ; Intracellular Fluid - metabolism ; Liposomes ; Mice ; Models, Biological ; Oocytes - chemistry ; Oocytes - metabolism ; Osmotic Pressure ; Water - metabolism</subject><ispartof>Biophysical journal, 1994-02, Vol.66 (2), p.532-541</ispartof><rights>1994 The Biophysical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-f6b859e4718139e8b897a12b3070746e8c76581a7efb8e5f0622ad6a2589c65d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1275720/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006349594808069$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,3537,27901,27902,53766,53768,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8161706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muldrew, K.</creatorcontrib><creatorcontrib>McGann, L.E.</creatorcontrib><title>The osmotic rupture hypothesis of intracellular freezing injury</title><title>Biophysical journal</title><addtitle>Biophys J</addtitle><description>A hypothesis of the nature of intracellular ice formation is proposed in which the osmotically driven water efflux that occurs in cells during freezing (caused by the increased osmotic pressure of the extracellular solution in the presence of ice) is viewed as the agent responsible for producing a rupture of the plasma membrane, thus allowing extracellular ice to propagate into the cytoplasm. This hypothesis is developed into a mathematical framework and the forces that are present during freezing are compared to the forces which are required to rupture membranes in circumstances unrelated to low temperatures. The theory is then applied to systems which have been previously studied to test implications of the theory on the nature of intracellular ice formation. The pressure that develops during freezing due to water flux is found to be sufficient to cause a rupture of the plasma membrane and the theory gives an accurate description of the phenomenology of intracellular ice formation.</description><subject>Animals</subject><subject>Biophysical Phenomena</subject><subject>Biophysics</subject><subject>Cell Line</subject><subject>Cell Membrane - metabolism</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>Female</subject><subject>Freezing</subject><subject>Ice</subject><subject>Intracellular Fluid - chemistry</subject><subject>Intracellular Fluid - metabolism</subject><subject>Liposomes</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Oocytes - chemistry</subject><subject>Oocytes - metabolism</subject><subject>Osmotic Pressure</subject><subject>Water - metabolism</subject><issn>0006-3495</issn><issn>1542-0086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EgvL4BKSsECwCYzd-bUAI8ZKQWABry3Em1CiNi51UKl9PSqsKVqxGnnvnzvgQckzhnAIVFy8AIPJxofmpLs4UqOGlt8iI8oLlAEpsk9HGskf2U_oAoIwD3SW7igoqQYzI1esEs5CmofMui_2s6yNmk8UsdBNMPmWhznzbReuwafrGxqyOiF--fR_aH31cHJKd2jYJj9b1gLzd3b7ePORPz_ePN9dPueNMdXktSsU1FpIqOtaoSqWlpawcgwRZCFROCq6olViXCnkNgjFbCcu40k7wanxALle5s76cYuVweVRjZtFPbVyYYL35q7R-Yt7D3FAmuWQwBJysA2L47DF1ZurT8le2xdAnI0XBGS34YOQro4shpYj1ZgkFsyRvfsibJVajC_ND3uhh7vj3hZupNepBv1rpOGCae4wmOY-tw8pHdJ2pgv9nwzej1ZRV</recordid><startdate>19940201</startdate><enddate>19940201</enddate><creator>Muldrew, K.</creator><creator>McGann, L.E.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19940201</creationdate><title>The osmotic rupture hypothesis of intracellular freezing injury</title><author>Muldrew, K. ; McGann, L.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-f6b859e4718139e8b897a12b3070746e8c76581a7efb8e5f0622ad6a2589c65d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biophysical Phenomena</topic><topic>Biophysics</topic><topic>Cell Line</topic><topic>Cell Membrane - metabolism</topic><topic>Cricetinae</topic><topic>Cricetulus</topic><topic>Female</topic><topic>Freezing</topic><topic>Ice</topic><topic>Intracellular Fluid - chemistry</topic><topic>Intracellular Fluid - metabolism</topic><topic>Liposomes</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Oocytes - chemistry</topic><topic>Oocytes - metabolism</topic><topic>Osmotic Pressure</topic><topic>Water - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muldrew, K.</creatorcontrib><creatorcontrib>McGann, L.E.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biophysical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muldrew, K.</au><au>McGann, L.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The osmotic rupture hypothesis of intracellular freezing injury</atitle><jtitle>Biophysical journal</jtitle><addtitle>Biophys J</addtitle><date>1994-02-01</date><risdate>1994</risdate><volume>66</volume><issue>2</issue><spage>532</spage><epage>541</epage><pages>532-541</pages><issn>0006-3495</issn><eissn>1542-0086</eissn><abstract>A hypothesis of the nature of intracellular ice formation is proposed in which the osmotically driven water efflux that occurs in cells during freezing (caused by the increased osmotic pressure of the extracellular solution in the presence of ice) is viewed as the agent responsible for producing a rupture of the plasma membrane, thus allowing extracellular ice to propagate into the cytoplasm. This hypothesis is developed into a mathematical framework and the forces that are present during freezing are compared to the forces which are required to rupture membranes in circumstances unrelated to low temperatures. The theory is then applied to systems which have been previously studied to test implications of the theory on the nature of intracellular ice formation. The pressure that develops during freezing due to water flux is found to be sufficient to cause a rupture of the plasma membrane and the theory gives an accurate description of the phenomenology of intracellular ice formation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8161706</pmid><doi>10.1016/S0006-3495(94)80806-9</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biophysical journal, 1994-02, Vol.66 (2), p.532-541 |
| issn | 0006-3495 1542-0086 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Biophysical Phenomena Biophysics Cell Line Cell Membrane - metabolism Cricetinae Cricetulus Female Freezing Ice Intracellular Fluid - chemistry Intracellular Fluid - metabolism Liposomes Mice Models, Biological Oocytes - chemistry Oocytes - metabolism Osmotic Pressure Water - metabolism |
| title | The osmotic rupture hypothesis of intracellular freezing injury |
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