Evaluation of Linkage and Association of HPC2/ELAC2 in Patients with Familial or Sporadic Prostate Cancer

To investigate the relationship between HPC2/ELAC2 and prostate cancer risk, we performed the following analyses: (1) a linkage study of six markers in and around the HPC2/ELAC2 gene at 17p11 in 159 pedigrees with hereditary prostate cancer (HPC); (2) a mutation-screening analysis of all coding exon...

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Veröffentlicht in:	American journal of human genetics 2001-04, Vol.68 (4), p.901-911
Hauptverfasser:	Xu, Jianfeng, Zheng, Siqun L., Carpten, John D., Nupponen, Nina N., Robbins, Christiane M., Mestre, Juanita, Moses, Tracy Y., Faith, Dennis A., Kelly, Brian D., Isaacs, Sarah D., Wiley, Kathleen E., Ewing, Charles M., Bujnovszky, Piroska, Chang, Bao-li, Bailey-Wilson, Joan, Bleecker, Eugene R., Walsh, Patrick C., Trent, Jeffrey M., Meyers, Deborah A., Isaacs, William B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Alleles Amino Acid Substitution - genetics Biological and medical sciences Chromosomes, Human, Pair 17 - genetics DNA Mutational Analysis Exons - genetics Gene Frequency - genetics Genetic Linkage - genetics Genetic Predisposition to Disease - genetics Genetic Testing Genotype Humans Lod Score Male Medical sciences Microsatellite Repeats - genetics Mutation - genetics Neoplasm Proteins - genetics Nephrology. Urinary tract diseases Pedigree Penetrance Polymorphism, Single Nucleotide - genetics Prostatic Neoplasms - epidemiology Prostatic Neoplasms - genetics Tumors of the urinary system Urinary tract. Prostate gland White People - genetics
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