Synapsis of DNA ends by DNA-dependent protein kinase

The catalytic subunit of DNA‐dependent protein kinase (DNA‐PKCS) is required for a non‐homologous end‐joining pathway that repairs DNA double‐strand breaks produced by ionizing radiation or V(D)J recombination; however, its role in this pathway has remained obscure. Using a neutravidin pull‐down ass...

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Veröffentlicht in:	The EMBO journal 2002-06, Vol.21 (12), p.3192-3200
Hauptverfasser:	DeFazio, Lisa G., Stansel, Rachel M., Griffith, Jack D., Chu, Gilbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Nuclear Chromosome Pairing - physiology Deoxyribonucleic acid DNA DNA - genetics DNA - metabolism DNA - ultrastructure DNA Damage DNA Helicases DNA Repair DNA-Activated Protein Kinase DNA-Binding Proteins - metabolism DNA-dependent protein kinase electron microscopy Enzyme Activation HeLa Cells Humans Ionizing radiation Ku Autoantigen Models, Genetic non-homologous end-joining Nuclear Proteins - metabolism Nucleic Acid Conformation Protein-Serine-Threonine Kinases - metabolism V(D)J recombination
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