Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein

The AML1–CBFβ transcription factor complex is the most frequent target of specific chromosome translocations in human leukemia. The MOZ gene, which encodes a histone acetyltransferase (HAT), is also involved in some leukemia‐associated translocations. We report here that MOZ is part of the AML1 comp...

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Veröffentlicht in:	The EMBO journal 2001-12, Vol.20 (24), p.7184-7196
Hauptverfasser:	Kitabayashi, Issay, Aikawa, Yukiko, Nguyen, Lan Anh, Yokoyama, Akihiko, Ohki, Misao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - chemistry Acetyltransferases - metabolism Amino Acid Sequence AML1 AML1 protein Base Sequence CBP protein Cell Differentiation Cell Line chromosome 16 chromosome 8 Core Binding Factor Alpha 2 Subunit CREB-Binding Protein DNA Primers DNA-Binding Proteins - physiology histone acetylation Histone Acetyltransferases Humans Leukemia Macrophages - cytology Molecular Sequence Data MOZ MOZ protein Nuclear Proteins - chemistry Nuclear Proteins - metabolism Proto-Oncogene Proteins Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Sequence Homology, Amino Acid Trans-Activators - chemistry Trans-Activators - metabolism Transcription Factors - physiology Transcriptional Activation - physiology Translocation
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