Serum Dioxin Concentrations and Age at Menopause
2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD), a halogenated compound that binds the aryl hydrocarbon receptor, is a by-product of numerous industrial processes including waste incineration. Studies in rats and monkeys suggest that TCDD may affect ovarian function. We examined the relationship of TCDD an...
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| Veröffentlicht in: | Environmental health perspectives 2005-07, Vol.113 (7), p.858-862 |
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| creator | Eskenazi, Brenda Warner, Marcella Marks, Amy R. Samuels, Steven Gerthoux, Pier Mario Vercellini, Paolo Olive, David L. Needham, Larry Patterson, Donald G. Mocarelli, Paolo |
| description | 2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD), a halogenated compound that binds the aryl hydrocarbon receptor, is a by-product of numerous industrial processes including waste incineration. Studies in rats and monkeys suggest that TCDD may affect ovarian function. We examined the relationship of TCDD and age at menopause in a population of women residing near Seveso, Italy, in 1976, at the time of a chemical plant explosion. We included 616 of the women who participated 20 years later in the Seveso Women's Health Study. All women were premenopausal at the time of the explosion, had TCDD levels measured in serum collected soon after the explosion, and were ≥ 35 years of age at interview. Using proportional hazards modeling, we found a 6% nonsignificant increase in risk of early menopause with a 10-fold increase in serum TCDD. When TCDD levels were categorized, compared with women in the lowest quintile (< 20.4 ppt), women in quintile 2 (20.4-34.2 ppt) had a hazard ratio (HR) of 1.1 (p = 0.77), quintile 3 (34.3-54.1 ppt) had an HR of 1.4 (p = 0.14), quintile 4 (54.2-118 ppt) had an HR of 1.6 (p = 0.10), and quintile 5 (> 118 ppt) had an HR of 1.1 (p = 0.82) for risk of earlier menopause. The trend toward earlier menopause across the first four quintiles is statistically significant (p = 0.04). These results suggest a nonmonotonic dose-related association with increasing risk of earlier menopause up to about 100 ppt TCDD, but not above. |
| doi_str_mv | 10.1289/ehp.7820 |
| format | Article |
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Studies in rats and monkeys suggest that TCDD may affect ovarian function. We examined the relationship of TCDD and age at menopause in a population of women residing near Seveso, Italy, in 1976, at the time of a chemical plant explosion. We included 616 of the women who participated 20 years later in the Seveso Women's Health Study. All women were premenopausal at the time of the explosion, had TCDD levels measured in serum collected soon after the explosion, and were ≥ 35 years of age at interview. Using proportional hazards modeling, we found a 6% nonsignificant increase in risk of early menopause with a 10-fold increase in serum TCDD. When TCDD levels were categorized, compared with women in the lowest quintile (< 20.4 ppt), women in quintile 2 (20.4-34.2 ppt) had a hazard ratio (HR) of 1.1 (p = 0.77), quintile 3 (34.3-54.1 ppt) had an HR of 1.4 (p = 0.14), quintile 4 (54.2-118 ppt) had an HR of 1.6 (p = 0.10), and quintile 5 (> 118 ppt) had an HR of 1.1 (p = 0.82) for risk of earlier menopause. The trend toward earlier menopause across the first four quintiles is statistically significant (p = 0.04). These results suggest a nonmonotonic dose-related association with increasing risk of earlier menopause up to about 100 ppt TCDD, but not above.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.7820</identifier><identifier>PMID: 16002373</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Adolescent ; Adult ; Age Factors ; Chemical hazards ; Chemical Industry ; Child ; Child, Preschool ; Dioxins ; Dosage ; Dose-Response Relationship, Drug ; Environmental health ; Environmental Pollutants - blood ; Explosions ; Female ; Health hazards ; Hormones ; Humans ; Infant ; Italy - epidemiology ; Menopause ; Menopause, Premature - blood ; Middle Aged ; Ovulation ; Polychlorinated Dibenzodioxins - blood ; Retrospective Studies ; Womens health ; Womens songs ; Workers' compensation</subject><ispartof>Environmental health perspectives, 2005-07, Vol.113 (7), p.858-862</ispartof><rights>COPYRIGHT 2005 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Jul 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c722t-9dc78bf59df949308205af345c33dc48c0880ac148dcdb6ecddfb223db98cb6b3</citedby><cites>FETCH-LOGICAL-c722t-9dc78bf59df949308205af345c33dc48c0880ac148dcdb6ecddfb223db98cb6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3436205$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3436205$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,864,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16002373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eskenazi, Brenda</creatorcontrib><creatorcontrib>Warner, Marcella</creatorcontrib><creatorcontrib>Marks, Amy R.</creatorcontrib><creatorcontrib>Samuels, Steven</creatorcontrib><creatorcontrib>Gerthoux, Pier Mario</creatorcontrib><creatorcontrib>Vercellini, Paolo</creatorcontrib><creatorcontrib>Olive, David L.</creatorcontrib><creatorcontrib>Needham, Larry</creatorcontrib><creatorcontrib>Patterson, Donald G.</creatorcontrib><creatorcontrib>Mocarelli, Paolo</creatorcontrib><title>Serum Dioxin Concentrations and Age at Menopause</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD), a halogenated compound that binds the aryl hydrocarbon receptor, is a by-product of numerous industrial processes including waste incineration. Studies in rats and monkeys suggest that TCDD may affect ovarian function. We examined the relationship of TCDD and age at menopause in a population of women residing near Seveso, Italy, in 1976, at the time of a chemical plant explosion. We included 616 of the women who participated 20 years later in the Seveso Women's Health Study. All women were premenopausal at the time of the explosion, had TCDD levels measured in serum collected soon after the explosion, and were ≥ 35 years of age at interview. Using proportional hazards modeling, we found a 6% nonsignificant increase in risk of early menopause with a 10-fold increase in serum TCDD. When TCDD levels were categorized, compared with women in the lowest quintile (< 20.4 ppt), women in quintile 2 (20.4-34.2 ppt) had a hazard ratio (HR) of 1.1 (p = 0.77), quintile 3 (34.3-54.1 ppt) had an HR of 1.4 (p = 0.14), quintile 4 (54.2-118 ppt) had an HR of 1.6 (p = 0.10), and quintile 5 (> 118 ppt) had an HR of 1.1 (p = 0.82) for risk of earlier menopause. The trend toward earlier menopause across the first four quintiles is statistically significant (p = 0.04). These results suggest a nonmonotonic dose-related association with increasing risk of earlier menopause up to about 100 ppt TCDD, but not above.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Chemical hazards</subject><subject>Chemical Industry</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dioxins</subject><subject>Dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Environmental health</subject><subject>Environmental Pollutants - blood</subject><subject>Explosions</subject><subject>Female</subject><subject>Health hazards</subject><subject>Hormones</subject><subject>Humans</subject><subject>Infant</subject><subject>Italy - epidemiology</subject><subject>Menopause</subject><subject>Menopause, Premature - blood</subject><subject>Middle Aged</subject><subject>Ovulation</subject><subject>Polychlorinated Dibenzodioxins - blood</subject><subject>Retrospective Studies</subject><subject>Womens health</subject><subject>Womens songs</subject><subject>Workers' compensation</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0l2L1DAUBuAgijuugj9ApHix6EXHfDVtboRh_FpYWXDV25Amp50MbTI2raz_3owd1h1ZUHpRaJ4cXnpehJ4SvCS0kq9hs1uWFcX30IIUBc2lpPw-WmAsSS5KUZygRzFuMcakEuIhOiECY8pKtkD4Coapz966cO18tg7egB8HPbrgY6a9zVYtZHrMPoEPOz1FeIweNLqL8OTwPkVf37_7sv6YX1x-OF-vLnJTUjrm0pqyqptC2kZyyXAKV-iG8cIwZg2vDK4qrA3hlTW2FmCsbWpKma1lZWpRs1P0Zp67m-oe7ByrU7vB9Xr4qYJ26vjEu41qww9FaFEKLtKAs8OAIXyfII6qd9FA12kPYYqKlJQQwvm_IS-5nOGLv-A2TINPf0FRSgUhTBQJ5TNqdQfK-SakdKYFDylk8NC49HlFWMFKidk-5vIOnx4LvTN3Xnh1dCGZEa7HNi0nqvOrz_9vL78d27NbdgO6GzcxdNPvKhzDlzM0Q4hxgOZmKQSrfR1VqqPa1zHR57eX-Ace-pfAsxls4xiGm3PGmUiFYb8AmMLgLQ</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Eskenazi, Brenda</creator><creator>Warner, Marcella</creator><creator>Marks, Amy R.</creator><creator>Samuels, Steven</creator><creator>Gerthoux, Pier Mario</creator><creator>Vercellini, Paolo</creator><creator>Olive, David L.</creator><creator>Needham, Larry</creator><creator>Patterson, Donald G.</creator><creator>Mocarelli, Paolo</creator><general>National Institute of Environmental Health Sciences. 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Perspect</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>113</volume><issue>7</issue><spage>858</spage><epage>862</epage><pages>858-862</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD), a halogenated compound that binds the aryl hydrocarbon receptor, is a by-product of numerous industrial processes including waste incineration. Studies in rats and monkeys suggest that TCDD may affect ovarian function. We examined the relationship of TCDD and age at menopause in a population of women residing near Seveso, Italy, in 1976, at the time of a chemical plant explosion. We included 616 of the women who participated 20 years later in the Seveso Women's Health Study. All women were premenopausal at the time of the explosion, had TCDD levels measured in serum collected soon after the explosion, and were ≥ 35 years of age at interview. Using proportional hazards modeling, we found a 6% nonsignificant increase in risk of early menopause with a 10-fold increase in serum TCDD. When TCDD levels were categorized, compared with women in the lowest quintile (< 20.4 ppt), women in quintile 2 (20.4-34.2 ppt) had a hazard ratio (HR) of 1.1 (p = 0.77), quintile 3 (34.3-54.1 ppt) had an HR of 1.4 (p = 0.14), quintile 4 (54.2-118 ppt) had an HR of 1.6 (p = 0.10), and quintile 5 (> 118 ppt) had an HR of 1.1 (p = 0.82) for risk of earlier menopause. The trend toward earlier menopause across the first four quintiles is statistically significant (p = 0.04). These results suggest a nonmonotonic dose-related association with increasing risk of earlier menopause up to about 100 ppt TCDD, but not above.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>16002373</pmid><doi>10.1289/ehp.7820</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Factors Chemical hazards Chemical Industry Child Child, Preschool Dioxins Dosage Dose-Response Relationship, Drug Environmental health Environmental Pollutants - blood Explosions Female Health hazards Hormones Humans Infant Italy - epidemiology Menopause Menopause, Premature - blood Middle Aged Ovulation Polychlorinated Dibenzodioxins - blood Retrospective Studies Womens health Womens songs Workers' compensation |
| title | Serum Dioxin Concentrations and Age at Menopause |
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