ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen

ShcA and Grb2 are crucial components in signalling by most tyrosine kinase‐associated receptors. How ever, it is not clear whether Grb2 bound directly to the receptor is equivalent to Grb2 associated via ShcA. We have used signalling stimulated by the middle T‐antigen (MT) of polyoma virus to addres...

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Veröffentlicht in:	The EMBO journal 2001-11, Vol.20 (22), p.6337-6346
Hauptverfasser:	Nicholson, Philippa R., Empereur, Sylvie, Glover, Hilary R., Dilworth, Stephen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino Acid Motifs Amino Acid Sequence Animals Binding Sites Blotting, Western Cell Membrane - metabolism Fibroblasts - metabolism Gab1 protein GRB2 Adaptor Protein Mice Molecular Sequence Data Phosphoproteins - metabolism Phosphorylation Plasmids - metabolism polyoma virus MT Polyomavirus Precipitin Tests Protein Binding Proteins - metabolism Rats Receptor, Epidermal Growth Factor - metabolism Sequence Homology, Amino Acid Shc Signaling Adaptor Proteins ShcA phosphorylation ShcA protein Signal Transduction SOS1 Protein - metabolism Src Homology 2 Domain-Containing, Transforming Protein 1 src Homology Domains transformation Tyrosine - metabolism
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