HBV infection of cell culture: evidence for multivalent and cooperative attachment

Hepadnaviruses do not infect cultured cells, therefore our knowledge of the mechanism of the early stages of virus–cell interaction is rather poor. In this study, we show that dimethylsulfoxide (DMSO)‐treated HepG2 hepatoblastoma cells are infected efficiently by serum‐derived hepatitis B virus (HBV...

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Veröffentlicht in:	The EMBO journal 2001-08, Vol.20 (16), p.4443-4453
Hauptverfasser:	Paran, Nir, Geiger, Benjamin, Shaul, Yosef
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Cell Culture Techniques Detergents - pharmacology Dimethyl Sulfoxide - pharmacology Endocytosis HBsAg proteins HBV infection Hepatitis B Surface Antigens - genetics Hepatitis B Surface Antigens - metabolism Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - metabolism Humans Ingestion Light microscopy Membrane Fusion - physiology Molecular Sequence Data Protein Precursors - genetics Protein Precursors - metabolism QLDPAF motif Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Tumor Cells, Cultured Virion virus attachment
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