Safety and immunogenicity of a vaccine bait containing ERA strain of attenuated rabies virus
Ninety percent of foxes fed commercial ERA vaccine in a specially designed bait developed rabies serum neutralizing antibodies. The vaccine bait did not cause clinical signs of rabies when consumed by foxes, raccoons, skunks, dogs, cats, cattle and monkeys. When presented, in the laboratory, to wild...
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| Veröffentlicht in: | Canadian journal of veterinary research 1987-10, Vol.51 (4), p.460-464 |
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| container_title | Canadian journal of veterinary research |
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| creator | Lawson, K.F Black, J.G Charlton, K.M Johnston, D.H Rhodes, A.J |
| description | Ninety percent of foxes fed commercial ERA vaccine in a specially designed bait developed rabies serum neutralizing antibodies. The vaccine bait did not cause clinical signs of rabies when consumed by foxes, raccoons, skunks, dogs, cats, cattle and monkeys. When presented, in the laboratory, to wild rodents of the species Microtus, Mus musculus and Peromyscus, the vaccine baits caused vaccine-induced rabies only in Mus musculus. Laboratory mice of the CD-1 and CLL strain were susceptible to vaccine-induced rabies; however, studies showed that transmission of virus to other animals did not occur. These studies suggest that the vaccine bait described could be useful in a rabies control program in areas where foxes and wild dogs are the principal vectors. |
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The vaccine bait did not cause clinical signs of rabies when consumed by foxes, raccoons, skunks, dogs, cats, cattle and monkeys. When presented, in the laboratory, to wild rodents of the species Microtus, Mus musculus and Peromyscus, the vaccine baits caused vaccine-induced rabies only in Mus musculus. Laboratory mice of the CD-1 and CLL strain were susceptible to vaccine-induced rabies; however, studies showed that transmission of virus to other animals did not occur. These studies suggest that the vaccine bait described could be useful in a rabies control program in areas where foxes and wild dogs are the principal vectors.</description><identifier>ISSN: 0830-9000</identifier><identifier>PMID: 3330965</identifier><language>eng</language><publisher>Canada</publisher><subject>Animals ; Animals, Wild - immunology ; Antibodies, Viral - biosynthesis ; Arvicolinae - immunology ; attenuation ; baits ; Cats ; Cattle ; Dogs ; Fluorescent Antibody Technique ; foxes ; Foxes - immunology ; immunity ; Lyssavirus ; Macaca mulatta - immunology ; Male ; Mephitidae - immunology ; Mice ; Peromyscus - immunology ; rabies ; Rabies Vaccines - administration & dosage ; Rabies Vaccines - adverse effects ; Rabies Vaccines - immunology ; rabies virus ; Rabies virus - immunology ; Raccoons - immunology ; strains ; vaccines ; Vaccines, Attenuated - administration & dosage ; Vaccines, Attenuated - adverse effects ; Vaccines, Attenuated - immunology</subject><ispartof>Canadian journal of veterinary research, 1987-10, Vol.51 (4), p.460-464</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1255365/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1255365/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3330965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lawson, K.F</creatorcontrib><creatorcontrib>Black, J.G</creatorcontrib><creatorcontrib>Charlton, K.M</creatorcontrib><creatorcontrib>Johnston, D.H</creatorcontrib><creatorcontrib>Rhodes, A.J</creatorcontrib><title>Safety and immunogenicity of a vaccine bait containing ERA strain of attenuated rabies virus</title><title>Canadian journal of veterinary research</title><addtitle>Can J Vet Res</addtitle><description>Ninety percent of foxes fed commercial ERA vaccine in a specially designed bait developed rabies serum neutralizing antibodies. The vaccine bait did not cause clinical signs of rabies when consumed by foxes, raccoons, skunks, dogs, cats, cattle and monkeys. When presented, in the laboratory, to wild rodents of the species Microtus, Mus musculus and Peromyscus, the vaccine baits caused vaccine-induced rabies only in Mus musculus. Laboratory mice of the CD-1 and CLL strain were susceptible to vaccine-induced rabies; however, studies showed that transmission of virus to other animals did not occur. These studies suggest that the vaccine bait described could be useful in a rabies control program in areas where foxes and wild dogs are the principal vectors.</description><subject>Animals</subject><subject>Animals, Wild - immunology</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>Arvicolinae - immunology</subject><subject>attenuation</subject><subject>baits</subject><subject>Cats</subject><subject>Cattle</subject><subject>Dogs</subject><subject>Fluorescent Antibody Technique</subject><subject>foxes</subject><subject>Foxes - immunology</subject><subject>immunity</subject><subject>Lyssavirus</subject><subject>Macaca mulatta - immunology</subject><subject>Male</subject><subject>Mephitidae - immunology</subject><subject>Mice</subject><subject>Peromyscus - immunology</subject><subject>rabies</subject><subject>Rabies Vaccines - administration & dosage</subject><subject>Rabies Vaccines - adverse effects</subject><subject>Rabies Vaccines - immunology</subject><subject>rabies virus</subject><subject>Rabies virus - immunology</subject><subject>Raccoons - immunology</subject><subject>strains</subject><subject>vaccines</subject><subject>Vaccines, Attenuated - administration & dosage</subject><subject>Vaccines, Attenuated - adverse effects</subject><subject>Vaccines, Attenuated - immunology</subject><issn>0830-9000</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhveg1Fr9CWJO3hby0U02F6GU-gEFwdqbEGazyRrZTeomW_Dfu9gievI0zLwvDw9zkk1xyXAuMcZn2XmM7xhTwSmbZBPGGJa8mGavG7AmfSLwNXJdN_jQGO-0G0_BIkB70Np5gypwCengEzjvfINWzwsUUz9u372UjB8gmRr1UDkT0d71Q7zITi200Vwe5yzb3q1elg_5-un-cblY55YRnvKq1pRT4IJAYQGD0ERCzTDjzHINBCirZEkMSFwCKZkwpqSFJLTmdF4Iy2bZ7YG7G6rO1Nr40axVu9510H-qAE79Tbx7U03YK0KLgvFiBNwcAX34GExMqnNRm7YFb8IQlSgxo0SKf4tkXo48wcfi1W-lH5fj48f8-pBbCAqa3kW13VBMGKaYSszn7Avgz4il</recordid><startdate>19871001</startdate><enddate>19871001</enddate><creator>Lawson, K.F</creator><creator>Black, J.G</creator><creator>Charlton, K.M</creator><creator>Johnston, D.H</creator><creator>Rhodes, A.J</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19871001</creationdate><title>Safety and immunogenicity of a vaccine bait containing ERA strain of attenuated rabies virus</title><author>Lawson, K.F ; Black, J.G ; Charlton, K.M ; Johnston, D.H ; Rhodes, A.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f316t-bdc262a671a5fa0a7c19ad30363f6ca1a23b981ea908a1837ee825912d62457f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Animals, Wild - immunology</topic><topic>Antibodies, Viral - biosynthesis</topic><topic>Arvicolinae - immunology</topic><topic>attenuation</topic><topic>baits</topic><topic>Cats</topic><topic>Cattle</topic><topic>Dogs</topic><topic>Fluorescent Antibody Technique</topic><topic>foxes</topic><topic>Foxes - immunology</topic><topic>immunity</topic><topic>Lyssavirus</topic><topic>Macaca mulatta - immunology</topic><topic>Male</topic><topic>Mephitidae - immunology</topic><topic>Mice</topic><topic>Peromyscus - immunology</topic><topic>rabies</topic><topic>Rabies Vaccines - administration & dosage</topic><topic>Rabies Vaccines - adverse effects</topic><topic>Rabies Vaccines - immunology</topic><topic>rabies virus</topic><topic>Rabies virus - immunology</topic><topic>Raccoons - immunology</topic><topic>strains</topic><topic>vaccines</topic><topic>Vaccines, Attenuated - administration & dosage</topic><topic>Vaccines, Attenuated - adverse effects</topic><topic>Vaccines, Attenuated - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lawson, K.F</creatorcontrib><creatorcontrib>Black, J.G</creatorcontrib><creatorcontrib>Charlton, K.M</creatorcontrib><creatorcontrib>Johnston, D.H</creatorcontrib><creatorcontrib>Rhodes, A.J</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian journal of veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lawson, K.F</au><au>Black, J.G</au><au>Charlton, K.M</au><au>Johnston, D.H</au><au>Rhodes, A.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety and immunogenicity of a vaccine bait containing ERA strain of attenuated rabies virus</atitle><jtitle>Canadian journal of veterinary research</jtitle><addtitle>Can J Vet Res</addtitle><date>1987-10-01</date><risdate>1987</risdate><volume>51</volume><issue>4</issue><spage>460</spage><epage>464</epage><pages>460-464</pages><issn>0830-9000</issn><abstract>Ninety percent of foxes fed commercial ERA vaccine in a specially designed bait developed rabies serum neutralizing antibodies. The vaccine bait did not cause clinical signs of rabies when consumed by foxes, raccoons, skunks, dogs, cats, cattle and monkeys. When presented, in the laboratory, to wild rodents of the species Microtus, Mus musculus and Peromyscus, the vaccine baits caused vaccine-induced rabies only in Mus musculus. Laboratory mice of the CD-1 and CLL strain were susceptible to vaccine-induced rabies; however, studies showed that transmission of virus to other animals did not occur. These studies suggest that the vaccine bait described could be useful in a rabies control program in areas where foxes and wild dogs are the principal vectors.</abstract><cop>Canada</cop><pmid>3330965</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Canadian journal of veterinary research, 1987-10, Vol.51 (4), p.460-464 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Animals, Wild - immunology Antibodies, Viral - biosynthesis Arvicolinae - immunology attenuation baits Cats Cattle Dogs Fluorescent Antibody Technique foxes Foxes - immunology immunity Lyssavirus Macaca mulatta - immunology Male Mephitidae - immunology Mice Peromyscus - immunology rabies Rabies Vaccines - administration & dosage Rabies Vaccines - adverse effects Rabies Vaccines - immunology rabies virus Rabies virus - immunology Raccoons - immunology strains vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - adverse effects Vaccines, Attenuated - immunology |
| title | Safety and immunogenicity of a vaccine bait containing ERA strain of attenuated rabies virus |
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