Patched1 interacts with cyclin B1 to regulate cell cycle progression

The initiation of mitosis requires the activation of M‐phase promoting factor (MPF). MPF activation and its subcellular localization are dependent on the phosphorylation state of its components, cdc2 and cyclin B1. In a two‐hybrid screen using a bait protein to mimic phosphorylated cyclin B1, we ide...

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Veröffentlicht in:	The EMBO journal 2001-05, Vol.20 (9), p.2214-2223
Hauptverfasser:	Barnes, Elizabeth A., Kong, Monica, Ollendorff, Vincent, Donoghue, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Baits basal cell carcinoma cdc2 gene Cell Cycle - drug effects Cell Cycle - physiology Cell Division - drug effects Cell Division - physiology Cell Line Cyclin B - metabolism Cyclin B1 cytoplasmic retention signal Hedgehog Proteins Humans Kidney - cytology Kidney - metabolism Life Sciences M checkpoint M-phase promoting factor Macromolecular Substances Maturation-Promoting Factor - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Proteins - pharmacology Mice nevoid basal cell carcinoma syndrome Patched Receptors Patched-1 Receptor patched1 gene Phosphorylation Precipitin Tests Protein Binding - drug effects Protein Binding - physiology Protein Structure, Tertiary - physiology Proteins - metabolism Proteins - pharmacology ptc1 gene Receptors, Cell Surface Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Trans-Activators Transfection Two-Hybrid System Techniques Xenopus
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