Visualizing the solvent-inaccessible core of a group II intron ribozyme

Group II introns are well recognized for their remarkable catalytic capabilities, but little is known about their three‐dimensional structures. In order to obtain a global view of an active enzyme, hydroxyl radical cleavage was used to define the solvent accessibility along the backbone of a ribozym...

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Veröffentlicht in:	The EMBO journal 2001-04, Vol.20 (8), p.2051-2061
Hauptverfasser:	Swisher, Jennifer, Duarte, Carlos M., Su, Linhui Julie, Pyle, Anna Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence catalysis Catalytic Domain Hydroxyl Radical hydroxyl radical footprinting Hydroxyl radicals Introns Models, Molecular molecular modeling Molecular Sequence Data Nucleic Acid Conformation RNA folding RNA, Catalytic - chemistry Solvents structure
Online-Zugang:	Volltext
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