Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na+ channel cell surface expression

The epithelial Na + channel (ENaC) plays an essential role in the regulation of whole body Na + balance and blood pressure. The cell surface expression of this channel, a complex of three subunits (α, β and γENaC), has been shown to be regulated by hormones such as aldosterone and vasopressin and by...

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Veröffentlicht in:	The EMBO journal 2001-12, Vol.20 (24), p.7052-7059
Hauptverfasser:	Debonneville, Christophe, Flores, Sandra Y., Kamynina, Elena, Plant, Pamela J., Tauxe, Caroline, Thomas, Marc A., Münster, Carole, Chraïbi, Ahmed, Pratt, J.Howard, Horisberger, Jean-Daniel, Pearce, David, Loffing, Johannes, Staub, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	aldosterone Amino Acid Sequence Animals Blood pressure Calcium-Binding Proteins - metabolism Cell Line - metabolism Endosomal Sorting Complexes Required for Transport Epithelial Sodium Channels Hormones Immediate-Early Proteins ion channel Ligases - metabolism Na+ transport Nedd4 Ubiquitin Protein Ligases Nuclear Proteins Oocytes - metabolism Phosphorylation Protein Binding Protein-Serine-Threonine Kinases - metabolism Sodium Channels - metabolism Ubiquitin - metabolism Ubiquitin-Protein Ligases ubiquitylation Xenopus laevis Xenopus Proteins
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