Control of the antral motor response to feeding by gastric acid secretion in rats
1. The motor response of the antrum to feeding was examined in relation to gastric acid content in six adult rats fitted with electrodes and strain gauges on the antrum, two of them also having a small cannula in the fundus. 2. After fasting overnight, feeding was accompanied by an immediate increas...
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| Veröffentlicht in: | The Journal of physiology 1982-04, Vol.325 (1), p.43-50 |
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| description | 1. The motor response of the antrum to feeding was examined in relation to gastric acid content in six adult rats fitted with
electrodes and strain gauges on the antrum, two of them also having a small cannula in the fundus. 2. After fasting overnight,
feeding was accompanied by an immediate increase in antral activity of seventeen to nineteen strong contractions lasting 5.33
+/- 1.15 min. Both the duration and amplitude of this antral motor response were increased 2 hr after ingestion of cimetidine
(20 mg/kg) or 60 min after intramuscular administration of the same dose of proglumide. 3. By contrast, the response to feeding
was reduced by 43% in duration and by 58% in amplitude during an intravenous infusion of pentagastrin (5 mg/kg per hr) and
disappeared after an infusion of HCl into the stomach. The area under the curve of the pressure developed by the gauge, used
as a motility index, was nearly doubled when the pH of the gastric contents increased from 3.1 to 5.7 and was halved when
the pH decreased from 3.1 to 2.2. 4. In normal or inhibitory gastric acid secretion, the blockade of the antral motor response
to feeding appeared when the total acid content of the gastric juice reached 35-70 mu equiv/ml. 5. The results indicated that
the rate of gastric secretion is of paramount importance in regulating the magnitude of the antral motor response to feeding.
It is suggested that the vagally stimulated antral motility is rapidly counteracted by the increased acid secretion. |
| doi_str_mv | 10.1113/jphysiol.1982.sp014134 |
| format | Article |
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electrodes and strain gauges on the antrum, two of them also having a small cannula in the fundus. 2. After fasting overnight,
feeding was accompanied by an immediate increase in antral activity of seventeen to nineteen strong contractions lasting 5.33
+/- 1.15 min. Both the duration and amplitude of this antral motor response were increased 2 hr after ingestion of cimetidine
(20 mg/kg) or 60 min after intramuscular administration of the same dose of proglumide. 3. By contrast, the response to feeding
was reduced by 43% in duration and by 58% in amplitude during an intravenous infusion of pentagastrin (5 mg/kg per hr) and
disappeared after an infusion of HCl into the stomach. The area under the curve of the pressure developed by the gauge, used
as a motility index, was nearly doubled when the pH of the gastric contents increased from 3.1 to 5.7 and was halved when
the pH decreased from 3.1 to 2.2. 4. In normal or inhibitory gastric acid secretion, the blockade of the antral motor response
to feeding appeared when the total acid content of the gastric juice reached 35-70 mu equiv/ml. 5. The results indicated that
the rate of gastric secretion is of paramount importance in regulating the magnitude of the antral motor response to feeding.
It is suggested that the vagally stimulated antral motility is rapidly counteracted by the increased acid secretion.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1982.sp014134</identifier><identifier>PMID: 7108783</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Action Potentials - drug effects ; Animals ; Cimetidine - pharmacology ; Eating ; Gastric Acid - metabolism ; Gastrointestinal Motility - drug effects ; Hydrochloric Acid - pharmacology ; Hydrogen-Ion Concentration ; Life Sciences ; Male ; Pentagastrin - pharmacology ; Proglumide - pharmacology ; Pyloric Antrum - physiology ; Rats ; Rats, Inbred Strains</subject><ispartof>The Journal of physiology, 1982-04, Vol.325 (1), p.43-50</ispartof><rights>1982 The Physiological Society</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5323-aa1a40c433e60dc549dc8a42dd5dd7371684b8862bef886595523fd00f151353</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1251378/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1251378/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7108783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02725268$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bueno, L</creatorcontrib><creatorcontrib>Ferre, J P</creatorcontrib><creatorcontrib>Fioramonti, J</creatorcontrib><creatorcontrib>Ruckesbusch, M</creatorcontrib><title>Control of the antral motor response to feeding by gastric acid secretion in rats</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. The motor response of the antrum to feeding was examined in relation to gastric acid content in six adult rats fitted with
electrodes and strain gauges on the antrum, two of them also having a small cannula in the fundus. 2. After fasting overnight,
feeding was accompanied by an immediate increase in antral activity of seventeen to nineteen strong contractions lasting 5.33
+/- 1.15 min. Both the duration and amplitude of this antral motor response were increased 2 hr after ingestion of cimetidine
(20 mg/kg) or 60 min after intramuscular administration of the same dose of proglumide. 3. By contrast, the response to feeding
was reduced by 43% in duration and by 58% in amplitude during an intravenous infusion of pentagastrin (5 mg/kg per hr) and
disappeared after an infusion of HCl into the stomach. The area under the curve of the pressure developed by the gauge, used
as a motility index, was nearly doubled when the pH of the gastric contents increased from 3.1 to 5.7 and was halved when
the pH decreased from 3.1 to 2.2. 4. In normal or inhibitory gastric acid secretion, the blockade of the antral motor response
to feeding appeared when the total acid content of the gastric juice reached 35-70 mu equiv/ml. 5. The results indicated that
the rate of gastric secretion is of paramount importance in regulating the magnitude of the antral motor response to feeding.
It is suggested that the vagally stimulated antral motility is rapidly counteracted by the increased acid secretion.</description><subject>Action Potentials - drug effects</subject><subject>Animals</subject><subject>Cimetidine - pharmacology</subject><subject>Eating</subject><subject>Gastric Acid - metabolism</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Hydrochloric Acid - pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Pentagastrin - pharmacology</subject><subject>Proglumide - pharmacology</subject><subject>Pyloric Antrum - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUcuO0zAUtRBoKIVPAHmFxCLF1488NkhVNTCgSoDUveXaTuNRGgfbnVH-Hpd0hseK1ZXveVwfHYTeAFkBAHt_O3ZTdL5fQVPTVRwJcGD8CVoAL5uiqhr2FC0IobRglYDn6EWMt4QAI01zha4qIHVVswX6vvFDCr7HvsWps1jll-rx0ScfcLBx9EO0OHncWmvccMD7CR9UTMFprLQzOFodbHJ-wG7AQaX4Ej1rVR_tq8tcot3H693mpth-_fR5s94WWjDKCqVAcaI5Y7YkRgveGF0rTo0RxlSsgrLm-7ou6d62eYhGCMpaQ0gLAphgS_Rhth1P-6M12v76uByDO6owSa-c_BsZXCcP_k4CzfqcfYnezQbdP7Kb9Vaed4RWVNCyvoPMfXs5FvyPk41JHl3Utu_VYP0pyopTLoCwTCxnog4-xmDbR2cg8tybfOhNnnuTD71l4es_4zzKLkVlfD3j966303-6yt2Xb-cFy5E5-52ic4fu3gUrZ1X02tk0yUyTIDPxJzzNuWM</recordid><startdate>19820401</startdate><enddate>19820401</enddate><creator>Bueno, L</creator><creator>Ferre, J P</creator><creator>Fioramonti, J</creator><creator>Ruckesbusch, M</creator><general>The Physiological Society</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope></search><sort><creationdate>19820401</creationdate><title>Control of the antral motor response to feeding by gastric acid secretion in rats</title><author>Bueno, L ; Ferre, J P ; Fioramonti, J ; Ruckesbusch, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5323-aa1a40c433e60dc549dc8a42dd5dd7371684b8862bef886595523fd00f151353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Action Potentials - drug effects</topic><topic>Animals</topic><topic>Cimetidine - pharmacology</topic><topic>Eating</topic><topic>Gastric Acid - metabolism</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Hydrochloric Acid - pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Pentagastrin - pharmacology</topic><topic>Proglumide - pharmacology</topic><topic>Pyloric Antrum - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bueno, L</creatorcontrib><creatorcontrib>Ferre, J P</creatorcontrib><creatorcontrib>Fioramonti, J</creatorcontrib><creatorcontrib>Ruckesbusch, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bueno, L</au><au>Ferre, J P</au><au>Fioramonti, J</au><au>Ruckesbusch, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Control of the antral motor response to feeding by gastric acid secretion in rats</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1982-04-01</date><risdate>1982</risdate><volume>325</volume><issue>1</issue><spage>43</spage><epage>50</epage><pages>43-50</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. The motor response of the antrum to feeding was examined in relation to gastric acid content in six adult rats fitted with
electrodes and strain gauges on the antrum, two of them also having a small cannula in the fundus. 2. After fasting overnight,
feeding was accompanied by an immediate increase in antral activity of seventeen to nineteen strong contractions lasting 5.33
+/- 1.15 min. Both the duration and amplitude of this antral motor response were increased 2 hr after ingestion of cimetidine
(20 mg/kg) or 60 min after intramuscular administration of the same dose of proglumide. 3. By contrast, the response to feeding
was reduced by 43% in duration and by 58% in amplitude during an intravenous infusion of pentagastrin (5 mg/kg per hr) and
disappeared after an infusion of HCl into the stomach. The area under the curve of the pressure developed by the gauge, used
as a motility index, was nearly doubled when the pH of the gastric contents increased from 3.1 to 5.7 and was halved when
the pH decreased from 3.1 to 2.2. 4. In normal or inhibitory gastric acid secretion, the blockade of the antral motor response
to feeding appeared when the total acid content of the gastric juice reached 35-70 mu equiv/ml. 5. The results indicated that
the rate of gastric secretion is of paramount importance in regulating the magnitude of the antral motor response to feeding.
It is suggested that the vagally stimulated antral motility is rapidly counteracted by the increased acid secretion.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>7108783</pmid><doi>10.1113/jphysiol.1982.sp014134</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of physiology, 1982-04, Vol.325 (1), p.43-50 |
| issn | 0022-3751 1469-7793 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Action Potentials - drug effects Animals Cimetidine - pharmacology Eating Gastric Acid - metabolism Gastrointestinal Motility - drug effects Hydrochloric Acid - pharmacology Hydrogen-Ion Concentration Life Sciences Male Pentagastrin - pharmacology Proglumide - pharmacology Pyloric Antrum - physiology Rats Rats, Inbred Strains |
| title | Control of the antral motor response to feeding by gastric acid secretion in rats |
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