Mechanisms leading to hypogonadism in men with burns injuries
A profound and persistent depression of serum testosterone concentrations was found in 19 men with burns injuries. This could not be explained by changes in sex hormone binding globulin capacity, hyperprolactinaemia, classical primary testicular failure, or a hypogonadotrophic state. Pulsatile relea...
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| Veröffentlicht in: | BMJ 1987-08, Vol.295 (6595), p.403-407 |
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| creator | Semple, C G Robertson, W R Mitchell, R Gordon, D Gray, C E Beastall, G H Reid, W H |
| description | A profound and persistent depression of serum testosterone concentrations was found in 19 men with burns injuries. This could not be explained by changes in sex hormone binding globulin capacity, hyperprolactinaemia, classical primary testicular failure, or a hypogonadotrophic state. Pulsatile release of luteinising hormone was found in control subjects but was absent or diminished in burnt patients with low serum testosterone concentrations. In addition, these patients showed reduced biological activity of luteinising hormone as measured by bioassay even though normal concentrations of luteinising hormone were detected by radioimmunoassay. The temporary hypogonadism after burns injury and possibly in other clinical states may be related to hypothalamic dysfunction, which leads to abnormal generation of luteinising hormone releasing hormone and non-pulsatile secretion of luteinising hormone of reduced biological activity. |
| doi_str_mv | 10.1136/bmj.295.6595.403 |
| format | Article |
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This could not be explained by changes in sex hormone binding globulin capacity, hyperprolactinaemia, classical primary testicular failure, or a hypogonadotrophic state. Pulsatile release of luteinising hormone was found in control subjects but was absent or diminished in burnt patients with low serum testosterone concentrations. In addition, these patients showed reduced biological activity of luteinising hormone as measured by bioassay even though normal concentrations of luteinising hormone were detected by radioimmunoassay. The temporary hypogonadism after burns injury and possibly in other clinical states may be related to hypothalamic dysfunction, which leads to abnormal generation of luteinising hormone releasing hormone and non-pulsatile secretion of luteinising hormone of reduced biological activity.</description><identifier>ISSN: 0267-0623</identifier><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>DOI: 10.1136/bmj.295.6595.403</identifier><identifier>PMID: 3115476</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Adult ; Aged ; Burns - blood ; Burns - complications ; Burns - physiopathology ; Clinical Research ; Diseases ; Follicle Stimulating Hormone - blood ; Follicles ; Globulins ; Gonadotropin-Releasing Hormone ; Hormones ; Humans ; Hypogonadism ; Hypogonadism - blood ; Hypogonadism - etiology ; Hypogonadism - physiopathology ; Hypothalamo-Hypophyseal System - physiopathology ; Luteinization ; Luteinizing Hormone - blood ; Male ; Middle Aged ; Physical trauma ; Secretion ; Sex Hormone-Binding Globulin - analysis ; Sex hormones ; Testosterone ; Testosterone - blood</subject><ispartof>BMJ, 1987-08, Vol.295 (6595), p.403-407</ispartof><rights>Copyright 1987 British Medical Journal</rights><rights>Copyright BMJ Publishing Group LTD Aug 15, 1987</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b515t-a057a3de1eb700b286f700b1c47689fabc1d92ef35a4e6b2f0c45497045360d23</citedby><cites>FETCH-LOGICAL-b515t-a057a3de1eb700b286f700b1c47689fabc1d92ef35a4e6b2f0c45497045360d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/29527933$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/29527933$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3115476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Semple, C G</creatorcontrib><creatorcontrib>Robertson, W R</creatorcontrib><creatorcontrib>Mitchell, R</creatorcontrib><creatorcontrib>Gordon, D</creatorcontrib><creatorcontrib>Gray, C E</creatorcontrib><creatorcontrib>Beastall, G H</creatorcontrib><creatorcontrib>Reid, W H</creatorcontrib><title>Mechanisms leading to hypogonadism in men with burns injuries</title><title>BMJ</title><addtitle>Br Med J (Clin Res Ed)</addtitle><description>A profound and persistent depression of serum testosterone concentrations was found in 19 men with burns injuries. This could not be explained by changes in sex hormone binding globulin capacity, hyperprolactinaemia, classical primary testicular failure, or a hypogonadotrophic state. Pulsatile release of luteinising hormone was found in control subjects but was absent or diminished in burnt patients with low serum testosterone concentrations. In addition, these patients showed reduced biological activity of luteinising hormone as measured by bioassay even though normal concentrations of luteinising hormone were detected by radioimmunoassay. The temporary hypogonadism after burns injury and possibly in other clinical states may be related to hypothalamic dysfunction, which leads to abnormal generation of luteinising hormone releasing hormone and non-pulsatile secretion of luteinising hormone of reduced biological activity.</description><subject>Adult</subject><subject>Aged</subject><subject>Burns - blood</subject><subject>Burns - complications</subject><subject>Burns - physiopathology</subject><subject>Clinical Research</subject><subject>Diseases</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Follicles</subject><subject>Globulins</subject><subject>Gonadotropin-Releasing Hormone</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypogonadism</subject><subject>Hypogonadism - blood</subject><subject>Hypogonadism - etiology</subject><subject>Hypogonadism - physiopathology</subject><subject>Hypothalamo-Hypophyseal System - physiopathology</subject><subject>Luteinization</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Physical trauma</subject><subject>Secretion</subject><subject>Sex Hormone-Binding Globulin - analysis</subject><subject>Sex hormones</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><issn>0267-0623</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFUU1v1DAUtBCorErvXJAiIXGpsvXzZ3IAqWz5qFRaIUHFzXISZ9chsRc7ofTf42hXW-DCxU9-M280o0HoOeAlABVn1dAtScmXgqeHYfoILYCJIucFpY_RAhMhcywIfYpOYuwwxoTKohTsCB1RAM6kWKDXn0y90c7GIWa90Y1162z02eZ-69fepX8cMuuywbjszo6brJqCi2nTTcGa-Aw9aXUfzcl-HqOv7999WX3Mr24-XK7Or_KKAx9zjbnUtDFgKolxRQrRzhPqZKEoW13V0JTEtJRrZkRFWlwzzkqJGacCN4Qeozc73e1UDaapjRuD7tU22EGHe-W1VX8jzm7U2v9UQJgkEpLAq71A8D8mE0c12FibvtfO-CmqAjAQEEUivvyH2PkUOYVTIKVggpVQJhbesergYwymPVgBrOZuVOpGpW7U3I1K3aSTF39GOBzsm3jAuzj6cICTBpElne_zHW7jaH4dcB2-KyGp5Or6dqXgVohvny_eqjnx6Y4_O_mvu9-Kq7Ao</recordid><startdate>19870815</startdate><enddate>19870815</enddate><creator>Semple, C G</creator><creator>Robertson, W R</creator><creator>Mitchell, R</creator><creator>Gordon, D</creator><creator>Gray, C E</creator><creator>Beastall, G H</creator><creator>Reid, W H</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19870815</creationdate><title>Mechanisms leading to hypogonadism in men with burns injuries</title><author>Semple, C G ; Robertson, W R ; Mitchell, R ; Gordon, D ; Gray, C E ; Beastall, G H ; Reid, W H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b515t-a057a3de1eb700b286f700b1c47689fabc1d92ef35a4e6b2f0c45497045360d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Burns - blood</topic><topic>Burns - complications</topic><topic>Burns - physiopathology</topic><topic>Clinical Research</topic><topic>Diseases</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Follicles</topic><topic>Globulins</topic><topic>Gonadotropin-Releasing Hormone</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hypogonadism</topic><topic>Hypogonadism - blood</topic><topic>Hypogonadism - etiology</topic><topic>Hypogonadism - physiopathology</topic><topic>Hypothalamo-Hypophyseal System - physiopathology</topic><topic>Luteinization</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Physical trauma</topic><topic>Secretion</topic><topic>Sex Hormone-Binding Globulin - analysis</topic><topic>Sex hormones</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Semple, C G</creatorcontrib><creatorcontrib>Robertson, W R</creatorcontrib><creatorcontrib>Mitchell, R</creatorcontrib><creatorcontrib>Gordon, D</creatorcontrib><creatorcontrib>Gray, C E</creatorcontrib><creatorcontrib>Beastall, G H</creatorcontrib><creatorcontrib>Reid, W H</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>ProQuest Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Semple, C G</au><au>Robertson, W R</au><au>Mitchell, R</au><au>Gordon, D</au><au>Gray, C E</au><au>Beastall, G H</au><au>Reid, W H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanisms leading to hypogonadism in men with burns injuries</atitle><jtitle>BMJ</jtitle><addtitle>Br Med J (Clin Res Ed)</addtitle><date>1987-08-15</date><risdate>1987</risdate><volume>295</volume><issue>6595</issue><spage>403</spage><epage>407</epage><pages>403-407</pages><issn>0267-0623</issn><issn>0959-8138</issn><eissn>1468-5833</eissn><abstract>A profound and persistent depression of serum testosterone concentrations was found in 19 men with burns injuries. This could not be explained by changes in sex hormone binding globulin capacity, hyperprolactinaemia, classical primary testicular failure, or a hypogonadotrophic state. Pulsatile release of luteinising hormone was found in control subjects but was absent or diminished in burnt patients with low serum testosterone concentrations. In addition, these patients showed reduced biological activity of luteinising hormone as measured by bioassay even though normal concentrations of luteinising hormone were detected by radioimmunoassay. The temporary hypogonadism after burns injury and possibly in other clinical states may be related to hypothalamic dysfunction, which leads to abnormal generation of luteinising hormone releasing hormone and non-pulsatile secretion of luteinising hormone of reduced biological activity.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>3115476</pmid><doi>10.1136/bmj.295.6595.403</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0267-0623 |
| ispartof | BMJ, 1987-08, Vol.295 (6595), p.403-407 |
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| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central |
| subjects | Adult Aged Burns - blood Burns - complications Burns - physiopathology Clinical Research Diseases Follicle Stimulating Hormone - blood Follicles Globulins Gonadotropin-Releasing Hormone Hormones Humans Hypogonadism Hypogonadism - blood Hypogonadism - etiology Hypogonadism - physiopathology Hypothalamo-Hypophyseal System - physiopathology Luteinization Luteinizing Hormone - blood Male Middle Aged Physical trauma Secretion Sex Hormone-Binding Globulin - analysis Sex hormones Testosterone Testosterone - blood |
| title | Mechanisms leading to hypogonadism in men with burns injuries |
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