Paracrine in vivo Inhibitory Effects of Hepatitis B Virus X Protein (HBx) on Liver Cell Proliferation: An Alternative Mechanism of HBx-Related Pathogenesis

The role of the hepatitis B virus X protein (HBx) in the pathogenesis of hepatitis B virus (HBV) infection remains unclear. HBx exhibits pleiotropic biological effects, whose in vivo relevance is a matter for debate. In the present report, we have used a combination of HBx-expressing transgenic mice...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-05, Vol.99 (10), p.6991-6996
Hauptverfasser:	Tralhao, J. Guilherme, Roudier, Jean, Morosan, Serban, Giannini, Carlo, Tu, Hong, Goulenok, Cyril, Carnot, Françoise, Zavala, Flora, Joulin, Virginie, Kremsdorf, Dina, Bréchot, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cell Division Cells Cells, Cultured DNA Female Gene Expression Hepatectomy Hepatitis Hepatitis B Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - metabolism Hepatocytes Hepatocytes - cytology Hepatocytes - metabolism Humans Liver Liver - cytology Liver - metabolism Liver - virology Liver cells Liver Regeneration Male Mice Mice, SCID Mice, Transgenic Paracrine Communication Pathology Proteins Rats Rats, Wistar Studies Trans-Activators - genetics Trans-Activators - metabolism Transgenes Transgenic animals Transplantation Tumor Cells, Cultured
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