Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus

Breach of B cell tolerance is central to the pathogenesis of systemic lupus erythematosus (SLE). However, how B cell tolerance is subverted in human SLE is poorly understood due to difficulties in identifying relevant autoreactive B cells and in obtaining lymphoid tissue. We have circumvented these...

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Veröffentlicht in:	The Journal of clinical investigation 2005-11, Vol.115 (11), p.3205-3216
Hauptverfasser:	Cappione, 3rd, Amedeo, Anolik, Jennifer H, Pugh-Bernard, Aimee, Barnard, Jennifer, Dutcher, Paul, Silverman, Gregg, Sanz, Iñaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Arthritis, Rheumatoid - immunology Autoantibodies - biosynthesis Autoantibodies - physiology B-Lymphocyte Subsets - cytology B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - pathology Biomedical research Cell Line Cell Proliferation Child, Preschool Clonal Anergy - immunology Clonal Deletion - immunology Female Genotype & phenotype Germinal Center - cytology Germinal Center - immunology Germinal Center - pathology Humans Immunoglobulin G - biosynthesis Immunoglobulin G - physiology Immunoglobulin M - biosynthesis Immunologic Memory - physiology Immunophenotyping Lupus Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Pathogenesis Physiology Plasma Spleen - cytology Spleen - immunology
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