Effect of Succimer on Growth of Preschool Children with Moderate Blood Lead Levels
Growth deficits associated with lead exposure might be ameliorated by chelation. We examined the effect of succimer on growth in 780 children 12-33 months old who had blood lead levels of 20-44 μg/dL and were randomized to receive up to three 26-day courses of succimer or placebo in a multicenter, d...
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| Veröffentlicht in: | Environmental health perspectives 2004-02, Vol.112 (2), p.233-237 |
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| creator | Peterson, Karen E. Salganik, Mikhail Campbell, Carla Rhoads, George G. Rubin, Judith Berger, Omer Ware, James H. Rogan, Walter |
| description | Growth deficits associated with lead exposure might be ameliorated by chelation. We examined the effect of succimer on growth in 780 children 12-33 months old who had blood lead levels of 20-44 μg/dL and were randomized to receive up to three 26-day courses of succimer or placebo in a multicenter, double-blind trial. The difference in changes in weight and height between succimer and placebo groups at 1-34 months was calculated by fitting cubic splines. The difference in height change in children on succimer compared with placebo was -0.27 cm [95% confidence interval (95% CI), -0.42 to -0.11] from baseline to 9 months, when 99% of children had completed treatment, and -0.43 cm (95% CI, -0.77 to -0.09) during 34 months of follow-up. Similar differences in weight gain were not statistically significant. Although succimer lowers blood lead in moderately lead-poisoned children, it does not have a beneficial effect on growth and may have an adverse effect. |
| doi_str_mv | 10.1289/ehp.6331 |
| format | Article |
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We examined the effect of succimer on growth in 780 children 12-33 months old who had blood lead levels of 20-44 μg/dL and were randomized to receive up to three 26-day courses of succimer or placebo in a multicenter, double-blind trial. The difference in changes in weight and height between succimer and placebo groups at 1-34 months was calculated by fitting cubic splines. The difference in height change in children on succimer compared with placebo was -0.27 cm [95% confidence interval (95% CI), -0.42 to -0.11] from baseline to 9 months, when 99% of children had completed treatment, and -0.43 cm (95% CI, -0.77 to -0.09) during 34 months of follow-up. Similar differences in weight gain were not statistically significant. Although succimer lowers blood lead in moderately lead-poisoned children, it does not have a beneficial effect on growth and may have an adverse effect.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.6331</identifier><identifier>PMID: 14754579</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Blood ; Body Height ; Body Weight ; Chelating Agents - adverse effects ; Chelating Agents - pharmacology ; Chelating Agents - therapeutic use ; Child Development ; Child growth ; Child nutrition ; Children ; Children's Health ; Double-Blind Method ; Environmental health ; Experimentation ; Female ; Growth - drug effects ; Humans ; Infant ; Lead ; Lead Poisoning - complications ; Lead Poisoning - drug therapy ; Male ; Nutrition ; Placebos ; Preschool children ; Succimer - adverse effects ; Succimer - pharmacology ; Succimer - therapeutic use ; Treatment Outcome</subject><ispartof>Environmental health perspectives, 2004-02, Vol.112 (2), p.233-237</ispartof><rights>COPYRIGHT 2004 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Feb 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c654t-18f5b63f6e8092635d94fcc9b912771e778f054510b0ebe4ffdf3dd1e219ffd03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3435566$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3435566$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,860,881,27903,27904,53769,53771,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14754579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peterson, Karen E.</creatorcontrib><creatorcontrib>Salganik, Mikhail</creatorcontrib><creatorcontrib>Campbell, Carla</creatorcontrib><creatorcontrib>Rhoads, George G.</creatorcontrib><creatorcontrib>Rubin, Judith</creatorcontrib><creatorcontrib>Berger, Omer</creatorcontrib><creatorcontrib>Ware, James H.</creatorcontrib><creatorcontrib>Rogan, Walter</creatorcontrib><title>Effect of Succimer on Growth of Preschool Children with Moderate Blood Lead Levels</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Growth deficits associated with lead exposure might be ameliorated by chelation. We examined the effect of succimer on growth in 780 children 12-33 months old who had blood lead levels of 20-44 μg/dL and were randomized to receive up to three 26-day courses of succimer or placebo in a multicenter, double-blind trial. The difference in changes in weight and height between succimer and placebo groups at 1-34 months was calculated by fitting cubic splines. The difference in height change in children on succimer compared with placebo was -0.27 cm [95% confidence interval (95% CI), -0.42 to -0.11] from baseline to 9 months, when 99% of children had completed treatment, and -0.43 cm (95% CI, -0.77 to -0.09) during 34 months of follow-up. Similar differences in weight gain were not statistically significant. Although succimer lowers blood lead in moderately lead-poisoned children, it does not have a beneficial effect on growth and may have an adverse effect.</description><subject>Blood</subject><subject>Body Height</subject><subject>Body Weight</subject><subject>Chelating Agents - adverse effects</subject><subject>Chelating Agents - pharmacology</subject><subject>Chelating Agents - therapeutic use</subject><subject>Child Development</subject><subject>Child growth</subject><subject>Child nutrition</subject><subject>Children</subject><subject>Children's Health</subject><subject>Double-Blind Method</subject><subject>Environmental health</subject><subject>Experimentation</subject><subject>Female</subject><subject>Growth - drug effects</subject><subject>Humans</subject><subject>Infant</subject><subject>Lead</subject><subject>Lead Poisoning - complications</subject><subject>Lead Poisoning - drug therapy</subject><subject>Male</subject><subject>Nutrition</subject><subject>Placebos</subject><subject>Preschool children</subject><subject>Succimer - adverse effects</subject><subject>Succimer - pharmacology</subject><subject>Succimer - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0v9r1DAUAPAiijun4B8gUvxh6A89kzRJm1-Eecw5OJls6q-hl75cc-SaW5Luy39vyh1zJwOlkIa8T15C3suy1xhNManFR-g2U16W-Ek2wYyRQghCn2YThAQueMXZQfYihBVCCNecP88OMK0YZZWYZBcnWoOKudP55aCUWYPPXZ-fencTu3H1u4egOudsPuuMbT30-Y1JoW-uBd9EyD9b59p8Ds04XIMNL7NnurEBXu3-h9nPLyc_Zl-L-fnp2ex4XijOaCxwrdmCl5pDjQThJWsF1UqJhcCkqjBUVa1RuiVGCwQLoFq3umxbDASLNEflYfZpm3czLNbQKuijb6zceLNu_J10jZH7kd50cumuJSYU1yVNCY52Cby7GiBEuTZBgbVND24IEleC8SrRf0LKa1pWJMF3f8GVG3yfXkESQjgjgouEii1aNhak6bVLt1NL6NN7WteDNmn5GGPKmCjZePr0EZ--FtZGPbrhw96GZCLcxmUzhCDPLi_-357_2rdHD2wHjY1dcHaIxvVhH77fQuVdCB70fVEwkmPDytSwcmzYRN8-LOIfuOvQBN5swSpE5-_jqXyMcV7-Blzz69U</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Peterson, Karen E.</creator><creator>Salganik, Mikhail</creator><creator>Campbell, Carla</creator><creator>Rhoads, George G.</creator><creator>Rubin, Judith</creator><creator>Berger, Omer</creator><creator>Ware, James H.</creator><creator>Rogan, Walter</creator><general>National Institute of Environmental Health Sciences. 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We examined the effect of succimer on growth in 780 children 12-33 months old who had blood lead levels of 20-44 μg/dL and were randomized to receive up to three 26-day courses of succimer or placebo in a multicenter, double-blind trial. The difference in changes in weight and height between succimer and placebo groups at 1-34 months was calculated by fitting cubic splines. The difference in height change in children on succimer compared with placebo was -0.27 cm [95% confidence interval (95% CI), -0.42 to -0.11] from baseline to 9 months, when 99% of children had completed treatment, and -0.43 cm (95% CI, -0.77 to -0.09) during 34 months of follow-up. Similar differences in weight gain were not statistically significant. Although succimer lowers blood lead in moderately lead-poisoned children, it does not have a beneficial effect on growth and may have an adverse effect.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>14754579</pmid><doi>10.1289/ehp.6331</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environmental health perspectives, 2004-02, Vol.112 (2), p.233-237 |
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| source | Jstor Complete Legacy; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Blood Body Height Body Weight Chelating Agents - adverse effects Chelating Agents - pharmacology Chelating Agents - therapeutic use Child Development Child growth Child nutrition Children Children's Health Double-Blind Method Environmental health Experimentation Female Growth - drug effects Humans Infant Lead Lead Poisoning - complications Lead Poisoning - drug therapy Male Nutrition Placebos Preschool children Succimer - adverse effects Succimer - pharmacology Succimer - therapeutic use Treatment Outcome |
| title | Effect of Succimer on Growth of Preschool Children with Moderate Blood Lead Levels |
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