Association between Arsenic Exposure from a Coal-Burning Power Plant and Urinary Arsenic Concentrations in Prievidza District, Slovakia
To assess the arsenic exposure of a population living in the vicinity of a coal-burning power plant with high arsenic emission in the Prievidza District, Slovakia, 548 spot urine samples were speciated for inorganic As (Asinorg), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and their su...
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| Veröffentlicht in: | Environmental health perspectives 2003-06, Vol.111 (7), p.889-894 |
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| creator | Ranft, Ulrich Miskovic, Peter Pesch, Beate Jakubis, Pavel Fabianova, Elenora Keegan, Tom Hergemöller, Andre Jakubis, Marian Nieuwenhuijsen, Mark J. The EXPASCAN Study Group |
| description | To assess the arsenic exposure of a population living in the vicinity of a coal-burning power plant with high arsenic emission in the Prievidza District, Slovakia, 548 spot urine samples were speciated for inorganic As (Asinorg), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and their sum (Assum). The urine samples were collected from the population of a case-control study on nonmelanoma skin cancer (NMSC). A total of 411 samples with complete As speciations and sufficient urine quality and without fish consumption were used for statistical analysis. Although current environmental As exposure and urinary As concentrations were low (median As in soil within 5 km distance to the power plant, 41 μg/g; median urinary Assum, 5.8 μg/L), there was a significant but weak association between As in soil and urinary Assum(r = 0.21, p < 0.01). We performed a multivariate regression analysis to calculate adjusted regression coefficients for environmental As exposure and other determinants of urinary As. Persons living in the vicinity of the plant had 27% higher Assumvalues (p < 0.01), based on elevated concentrations of the methylated species. A 32% increase of MMA occurred among subjects who consumed homegrown food (p < 0.001). NMSC cases had significantly higher levels of Assum, DMA, and Asinorg. The methylation index Asinorg/( MMA+ DMA) was about 20% lower among cases (p < 0.05) and in men (p < 0.05) compared with controls and females, respectively. |
| doi_str_mv | 10.1289/ehp.5838 |
| format | Article |
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The urine samples were collected from the population of a case-control study on nonmelanoma skin cancer (NMSC). A total of 411 samples with complete As speciations and sufficient urine quality and without fish consumption were used for statistical analysis. Although current environmental As exposure and urinary As concentrations were low (median As in soil within 5 km distance to the power plant, 41 μg/g; median urinary Assum, 5.8 μg/L), there was a significant but weak association between As in soil and urinary Assum(r = 0.21, p < 0.01). We performed a multivariate regression analysis to calculate adjusted regression coefficients for environmental As exposure and other determinants of urinary As. Persons living in the vicinity of the plant had 27% higher Assumvalues (p < 0.01), based on elevated concentrations of the methylated species. A 32% increase of MMA occurred among subjects who consumed homegrown food (p < 0.001). NMSC cases had significantly higher levels of Assum, DMA, and Asinorg. The methylation index Asinorg/( MMA+ DMA) was about 20% lower among cases (p < 0.05) and in men (p < 0.05) compared with controls and females, respectively.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.5838</identifier><identifier>PMID: 12782488</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Air Pollutants - poisoning ; Air Pollutants - urine ; Arsenic ; Arsenic Poisoning - urine ; Biomarkers ; Body Burden ; Case-Control Studies ; Chemical hazards ; Coal ; Environmental Exposure - adverse effects ; Environmental Exposure - analysis ; Environmental Health ; Excretion ; Female ; Food consumption ; Humans ; Male ; Methylation ; Middle Aged ; Potable water ; Power Plants ; Slovakia ; Soil samples ; Speciation ; Urine</subject><ispartof>Environmental health perspectives, 2003-06, Vol.111 (7), p.889-894</ispartof><rights>COPYRIGHT 2003 National Institute of Environmental Health Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c627t-726f241f052866e7cae1ce17777e317f92fb32756d22acadf3bafe47adfe173c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3435161$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3435161$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,860,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12782488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ranft, Ulrich</creatorcontrib><creatorcontrib>Miskovic, Peter</creatorcontrib><creatorcontrib>Pesch, Beate</creatorcontrib><creatorcontrib>Jakubis, Pavel</creatorcontrib><creatorcontrib>Fabianova, Elenora</creatorcontrib><creatorcontrib>Keegan, Tom</creatorcontrib><creatorcontrib>Hergemöller, Andre</creatorcontrib><creatorcontrib>Jakubis, Marian</creatorcontrib><creatorcontrib>Nieuwenhuijsen, Mark J.</creatorcontrib><creatorcontrib>The EXPASCAN Study Group</creatorcontrib><creatorcontrib>EXPASCAN Study Group</creatorcontrib><title>Association between Arsenic Exposure from a Coal-Burning Power Plant and Urinary Arsenic Concentrations in Prievidza District, Slovakia</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>To assess the arsenic exposure of a population living in the vicinity of a coal-burning power plant with high arsenic emission in the Prievidza District, Slovakia, 548 spot urine samples were speciated for inorganic As (Asinorg), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and their sum (Assum). The urine samples were collected from the population of a case-control study on nonmelanoma skin cancer (NMSC). A total of 411 samples with complete As speciations and sufficient urine quality and without fish consumption were used for statistical analysis. Although current environmental As exposure and urinary As concentrations were low (median As in soil within 5 km distance to the power plant, 41 μg/g; median urinary Assum, 5.8 μg/L), there was a significant but weak association between As in soil and urinary Assum(r = 0.21, p < 0.01). We performed a multivariate regression analysis to calculate adjusted regression coefficients for environmental As exposure and other determinants of urinary As. Persons living in the vicinity of the plant had 27% higher Assumvalues (p < 0.01), based on elevated concentrations of the methylated species. A 32% increase of MMA occurred among subjects who consumed homegrown food (p < 0.001). NMSC cases had significantly higher levels of Assum, DMA, and Asinorg. The methylation index Asinorg/( MMA+ DMA) was about 20% lower among cases (p < 0.05) and in men (p < 0.05) compared with controls and females, respectively.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Air Pollutants - poisoning</subject><subject>Air Pollutants - urine</subject><subject>Arsenic</subject><subject>Arsenic Poisoning - urine</subject><subject>Biomarkers</subject><subject>Body Burden</subject><subject>Case-Control Studies</subject><subject>Chemical hazards</subject><subject>Coal</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Exposure - analysis</subject><subject>Environmental Health</subject><subject>Excretion</subject><subject>Female</subject><subject>Food consumption</subject><subject>Humans</subject><subject>Male</subject><subject>Methylation</subject><subject>Middle Aged</subject><subject>Potable water</subject><subject>Power Plants</subject><subject>Slovakia</subject><subject>Soil samples</subject><subject>Speciation</subject><subject>Urine</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt1u0zAUxyMEYt1A4gEQ8tUEEimxnTjJDVLpBkyatIoxbi3XOW49ErvYTjd4AV4bd6nKKk0C39jy-Z3_-UySFzgbY1LV72C5GhcVrR4lI1wUJK1rkj9ORllW45SVrDhIDr2_zrIMV4w9TQ4wKSuSV9Uo-T3x3kotgrYGzSHcABg0cR6Mluj0dmV97wApZzsk0NSKNv3QO6PNAs3sDTg0a4UJSJgGXTlthPu5c55aI8EEdyftkTZo5jSsdfNLoBPtg9MyvEWXrV2L71o8S54o0Xp4vr2PkquPp1-nn9Pzi09n08l5KhkpQ1oSpkiOVVaQWAmUUgCWgMt4gOJS1UTNKSkL1hAipGgUnQsFeRlfkaKSHiXvB91VP--gGTJs-crpLibPrdB832L0ki_smuMYtiA4ChxvBZz90YMPvNNeQhv7ALb3HFcVrmgcxj_BnDFaEBbBdAAXogWujbIxsFyAgRjfGlA6fk9wVmBGMroRHj_Ab6qFTssHHd7sOUQmwG1YiN57fnb55f_Zi2_77PE9dgmiDUtv2_5u4Pvg6wGUznrvQO36jTO-WWAeF5hvFjiir-7P5y-43dgIvByAax-s29lpTmM0TP8Azsb08g</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Ranft, Ulrich</creator><creator>Miskovic, Peter</creator><creator>Pesch, Beate</creator><creator>Jakubis, Pavel</creator><creator>Fabianova, Elenora</creator><creator>Keegan, Tom</creator><creator>Hergemöller, Andre</creator><creator>Jakubis, Marian</creator><creator>Nieuwenhuijsen, Mark J.</creator><creator>The EXPASCAN Study Group</creator><general>National Institute of Environmental Health Sciences. National Institutes of Health. 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The urine samples were collected from the population of a case-control study on nonmelanoma skin cancer (NMSC). A total of 411 samples with complete As speciations and sufficient urine quality and without fish consumption were used for statistical analysis. Although current environmental As exposure and urinary As concentrations were low (median As in soil within 5 km distance to the power plant, 41 μg/g; median urinary Assum, 5.8 μg/L), there was a significant but weak association between As in soil and urinary Assum(r = 0.21, p < 0.01). We performed a multivariate regression analysis to calculate adjusted regression coefficients for environmental As exposure and other determinants of urinary As. Persons living in the vicinity of the plant had 27% higher Assumvalues (p < 0.01), based on elevated concentrations of the methylated species. A 32% increase of MMA occurred among subjects who consumed homegrown food (p < 0.001). NMSC cases had significantly higher levels of Assum, DMA, and Asinorg. The methylation index Asinorg/( MMA+ DMA) was about 20% lower among cases (p < 0.05) and in men (p < 0.05) compared with controls and females, respectively.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>12782488</pmid><doi>10.1289/ehp.5838</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Air Pollutants - poisoning Air Pollutants - urine Arsenic Arsenic Poisoning - urine Biomarkers Body Burden Case-Control Studies Chemical hazards Coal Environmental Exposure - adverse effects Environmental Exposure - analysis Environmental Health Excretion Female Food consumption Humans Male Methylation Middle Aged Potable water Power Plants Slovakia Soil samples Speciation Urine |
| title | Association between Arsenic Exposure from a Coal-Burning Power Plant and Urinary Arsenic Concentrations in Prievidza District, Slovakia |
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