Problems for Risk Assessment of Endocrine-Active Estrogenic Compounds

Estrogenic industrial compounds such as bisphenol A (BPA) and nonylphenol typically bind estrogen receptor (ER) α and ERβ and induce transactivation of estrogen-responsive genes/reporter genes, but their potencies are usually ≥ 1000-fold lower than observed for 17β-estradiol. Risk assessment of estr...

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Veröffentlicht in:	Environmental health perspectives 2002-12, Vol.110 (Suppl 6), p.925-929
Hauptverfasser:	Safe, Stephen H., Pallaroni, Lea, Yoon, Kyungsil, Gaido, Kevin, Ross, Susan, McDonnell, Donald
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Application of Cell and Molecular Technology to Chemical Mixtures Biological Assay Carcinoma, Hepatocellular - pathology Cell lines Chemical hazards Dose-Response Relationship, Drug Drug interactions Endocrine System - drug effects Estrogen receptors Estrogens Estrogens, Non-Steroidal - adverse effects Hep G2 cells Humans Isoflavones Ligands Liver Neoplasms - pathology Luciferases Phytoestrogens Plant Preparations Promoter Regions, Genetic Receptors Receptors, Estrogen - drug effects Receptors, Estrogen - physiology Risk analysis Risk Assessment Structure-Activity Relationship Transfection Tumor Cells, Cultured
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