Modulation of Airway Sensitivity to Inhaled Irritants: Role of Inflammatory Mediators

Bronchopulmonary C-fiber endings and rapidly adapting pulmonary receptors (RARs) are primarily responsible for eliciting the defense reflexes in protecting the lungs against inhaled irritants. In anesthetized animals, inhalation of cigarette smoke, one of the common inhaled irritants, into the lungs...

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Veröffentlicht in:	Environmental health perspectives 2001-08, Vol.109 (suppl 4), p.585-589
Hauptverfasser:	Lee, Lu-Yuan, Widdicombe, John G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation of Neural Pathways by Inhalation of Allergens and Irritants Air Pollutants - adverse effects Animals Bronchial Hyperreactivity - chemically induced Bronchial Hyperreactivity - physiopathology Cats Cigarette smoking Cigarettes Disease Models, Animal Dogs Histamines Humans Inhalation Irritants - adverse effects irritation Lung - drug effects Lung - innervation Lungs Nerve Fibers - drug effects Nerve Fibers - physiology Ozone Ozone - adverse effects Rats Receptors Reflex - drug effects Reflexes Respiratory reflexes Tobacco Smoke Pollution - adverse effects Unmyelinated nerve fibers
Online-Zugang:	Volltext
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