Disposition of Orally Administered 2,2-Bis(4-Hydroxyphenyl)Propane (Bisphenol A) in Pregnant Rats and the Placental Transfer to Fetuses
We studied the disposition of bisphenol A (BPA) in pregnant female F344/DuCrj(Fischer) rats and its placental transfer to fetuses after a single oral administration of 1 g/kg BPA dissolved in propylene glycol. BPA in maternal blood, liver, and kidney reached maximal concentrations (14.7, 171, and 36...
Gespeichert in:
| Veröffentlicht in: | Environmental health perspectives 2000-10, Vol.108 (10), p.931-935 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 935 |
|---|---|
| container_issue | 10 |
| container_start_page | 931 |
| container_title | Environmental health perspectives |
| container_volume | 108 |
| creator | Takahashi, Osamu Oishi, Shinshi |
| description | We studied the disposition of bisphenol A (BPA) in pregnant female F344/DuCrj(Fischer) rats and its placental transfer to fetuses after a single oral administration of 1 g/kg BPA dissolved in propylene glycol. BPA in maternal blood, liver, and kidney reached maximal concentrations (14.7, 171, and 36μg/g) 20 min after the administration and gradually decreased. The levels were 2-5% of the maximum 6 hr after the administration. The maximal concentration of BPA in fetuses (9 μg/g) was also attained 20 min after the administration. BPA levels then gradually reduced in a similar manner to maternal blood. These results suggest that the absorption and distribution of BPA in maternal organs and fetuses are extremely rapid and that the placenta does not act as a barrier to BPA. |
| doi_str_mv | 10.1289/ehp.00108931 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1240124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A68148361</galeid><jstor_id>3435050</jstor_id><sourcerecordid>A68148361</sourcerecordid><originalsourceid>FETCH-LOGICAL-c536t-7589fc5d93be6011174b6f31732371ebf8d8a5181f38f67e866afcfe6277b1f83</originalsourceid><addsrcrecordid>eNpVkdFrFDEQxhdR7LX65rPkQUsL3ZrZbLLZF-Gs1gqFHlKfQ253cpuS26xJTry_wH_bHHdqfRgGZn58zDdfUbwCegmVbN_hMF1SClS2DJ4UM-C8Ktu2qp8WM0pbKEUj-FFxHOMDzZgU4nlxBEDrVgLMil8fbZx8tMn6kXhD7oJ2bkvm_dqONiYM2JPqoio_2HhWlzfbPvif22nAcevOF8FPekRylpe7kXdkfk7sSBYBV6MeE_mqUyR67EkakCyc7nBM2pH7oMdoMJDkyTWmTcT4onhmtIv48tBPim_Xn-6vbsrbu89frua3ZceZSGXDZWs63rdsiYICQFMvhWHQsIo1gEsje6k5SDBMGtFgtqtNZ1BUTbMEI9lJ8X6vO22Wa-x3B2XHagp2rcNWeW3V_5vRDmrlfyioaporC5weBIL_vsGY1NrGDp3Ln_CbqKDmvJY1ZPDtHlxph2pA7dIQvdvsPh3VXEioJRM77mLPdcHHGND8PQao2iWscsLqT8IZf_3YwD_4EGkG3uyBh5h8eCxWMdooVjNOOWW_AcHarcw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14554841</pqid></control><display><type>article</type><title>Disposition of Orally Administered 2,2-Bis(4-Hydroxyphenyl)Propane (Bisphenol A) in Pregnant Rats and the Placental Transfer to Fetuses</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Takahashi, Osamu ; Oishi, Shinshi</creator><creatorcontrib>Takahashi, Osamu ; Oishi, Shinshi</creatorcontrib><description>We studied the disposition of bisphenol A (BPA) in pregnant female F344/DuCrj(Fischer) rats and its placental transfer to fetuses after a single oral administration of 1 g/kg BPA dissolved in propylene glycol. BPA in maternal blood, liver, and kidney reached maximal concentrations (14.7, 171, and 36μg/g) 20 min after the administration and gradually decreased. The levels were 2-5% of the maximum 6 hr after the administration. The maximal concentration of BPA in fetuses (9 μg/g) was also attained 20 min after the administration. BPA levels then gradually reduced in a similar manner to maternal blood. These results suggest that the absorption and distribution of BPA in maternal organs and fetuses are extremely rapid and that the placenta does not act as a barrier to BPA.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.00108931</identifier><identifier>PMID: 11049811</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Absorption ; Administration, Oral ; Air Pollutants, Occupational - pharmacokinetics ; Animals ; Benzhydryl Compounds ; Bisphenols ; Blood ; Business publications audits ; Chemical hazards ; Dosage ; Female ; Fetus ; Liver ; Maternal-Fetal Exchange ; Phenols - pharmacokinetics ; Placenta ; Placenta - physiology ; Pregnancy ; Rats ; Rats, Inbred F344 ; Time Factors ; Tissue Distribution ; Toxicology</subject><ispartof>Environmental health perspectives, 2000-10, Vol.108 (10), p.931-935</ispartof><rights>COPYRIGHT 2000 National Institute of Environmental Health Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-7589fc5d93be6011174b6f31732371ebf8d8a5181f38f67e866afcfe6277b1f83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3435050$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3435050$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,860,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11049811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahashi, Osamu</creatorcontrib><creatorcontrib>Oishi, Shinshi</creatorcontrib><title>Disposition of Orally Administered 2,2-Bis(4-Hydroxyphenyl)Propane (Bisphenol A) in Pregnant Rats and the Placental Transfer to Fetuses</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>We studied the disposition of bisphenol A (BPA) in pregnant female F344/DuCrj(Fischer) rats and its placental transfer to fetuses after a single oral administration of 1 g/kg BPA dissolved in propylene glycol. BPA in maternal blood, liver, and kidney reached maximal concentrations (14.7, 171, and 36μg/g) 20 min after the administration and gradually decreased. The levels were 2-5% of the maximum 6 hr after the administration. The maximal concentration of BPA in fetuses (9 μg/g) was also attained 20 min after the administration. BPA levels then gradually reduced in a similar manner to maternal blood. These results suggest that the absorption and distribution of BPA in maternal organs and fetuses are extremely rapid and that the placenta does not act as a barrier to BPA.</description><subject>Absorption</subject><subject>Administration, Oral</subject><subject>Air Pollutants, Occupational - pharmacokinetics</subject><subject>Animals</subject><subject>Benzhydryl Compounds</subject><subject>Bisphenols</subject><subject>Blood</subject><subject>Business publications audits</subject><subject>Chemical hazards</subject><subject>Dosage</subject><subject>Female</subject><subject>Fetus</subject><subject>Liver</subject><subject>Maternal-Fetal Exchange</subject><subject>Phenols - pharmacokinetics</subject><subject>Placenta</subject><subject>Placenta - physiology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Time Factors</subject><subject>Tissue Distribution</subject><subject>Toxicology</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkdFrFDEQxhdR7LX65rPkQUsL3ZrZbLLZF-Gs1gqFHlKfQ253cpuS26xJTry_wH_bHHdqfRgGZn58zDdfUbwCegmVbN_hMF1SClS2DJ4UM-C8Ktu2qp8WM0pbKEUj-FFxHOMDzZgU4nlxBEDrVgLMil8fbZx8tMn6kXhD7oJ2bkvm_dqONiYM2JPqoio_2HhWlzfbPvif22nAcevOF8FPekRylpe7kXdkfk7sSBYBV6MeE_mqUyR67EkakCyc7nBM2pH7oMdoMJDkyTWmTcT4onhmtIv48tBPim_Xn-6vbsrbu89frua3ZceZSGXDZWs63rdsiYICQFMvhWHQsIo1gEsje6k5SDBMGtFgtqtNZ1BUTbMEI9lJ8X6vO22Wa-x3B2XHagp2rcNWeW3V_5vRDmrlfyioaporC5weBIL_vsGY1NrGDp3Ln_CbqKDmvJY1ZPDtHlxph2pA7dIQvdvsPh3VXEioJRM77mLPdcHHGND8PQao2iWscsLqT8IZf_3YwD_4EGkG3uyBh5h8eCxWMdooVjNOOWW_AcHarcw</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Takahashi, Osamu</creator><creator>Oishi, Shinshi</creator><general>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</general><general>National Institute of Environmental Health Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>5PM</scope></search><sort><creationdate>20001001</creationdate><title>Disposition of Orally Administered 2,2-Bis(4-Hydroxyphenyl)Propane (Bisphenol A) in Pregnant Rats and the Placental Transfer to Fetuses</title><author>Takahashi, Osamu ; Oishi, Shinshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-7589fc5d93be6011174b6f31732371ebf8d8a5181f38f67e866afcfe6277b1f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Absorption</topic><topic>Administration, Oral</topic><topic>Air Pollutants, Occupational - pharmacokinetics</topic><topic>Animals</topic><topic>Benzhydryl Compounds</topic><topic>Bisphenols</topic><topic>Blood</topic><topic>Business publications audits</topic><topic>Chemical hazards</topic><topic>Dosage</topic><topic>Female</topic><topic>Fetus</topic><topic>Liver</topic><topic>Maternal-Fetal Exchange</topic><topic>Phenols - pharmacokinetics</topic><topic>Placenta</topic><topic>Placenta - physiology</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Time Factors</topic><topic>Tissue Distribution</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi, Osamu</creatorcontrib><creatorcontrib>Oishi, Shinshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Osamu</au><au>Oishi, Shinshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disposition of Orally Administered 2,2-Bis(4-Hydroxyphenyl)Propane (Bisphenol A) in Pregnant Rats and the Placental Transfer to Fetuses</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>108</volume><issue>10</issue><spage>931</spage><epage>935</epage><pages>931-935</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>We studied the disposition of bisphenol A (BPA) in pregnant female F344/DuCrj(Fischer) rats and its placental transfer to fetuses after a single oral administration of 1 g/kg BPA dissolved in propylene glycol. BPA in maternal blood, liver, and kidney reached maximal concentrations (14.7, 171, and 36μg/g) 20 min after the administration and gradually decreased. The levels were 2-5% of the maximum 6 hr after the administration. The maximal concentration of BPA in fetuses (9 μg/g) was also attained 20 min after the administration. BPA levels then gradually reduced in a similar manner to maternal blood. These results suggest that the absorption and distribution of BPA in maternal organs and fetuses are extremely rapid and that the placenta does not act as a barrier to BPA.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>11049811</pmid><doi>10.1289/ehp.00108931</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 2000-10, Vol.108 (10), p.931-935 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1240124 |
| source | Jstor Complete Legacy; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Absorption Administration, Oral Air Pollutants, Occupational - pharmacokinetics Animals Benzhydryl Compounds Bisphenols Blood Business publications audits Chemical hazards Dosage Female Fetus Liver Maternal-Fetal Exchange Phenols - pharmacokinetics Placenta Placenta - physiology Pregnancy Rats Rats, Inbred F344 Time Factors Tissue Distribution Toxicology |
| title | Disposition of Orally Administered 2,2-Bis(4-Hydroxyphenyl)Propane (Bisphenol A) in Pregnant Rats and the Placental Transfer to Fetuses |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T17%3A14%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Disposition%20of%20Orally%20Administered%202,2-Bis(4-Hydroxyphenyl)Propane%20(Bisphenol%20A)%20in%20Pregnant%20Rats%20and%20the%20Placental%20Transfer%20to%20Fetuses&rft.jtitle=Environmental%20health%20perspectives&rft.au=Takahashi,%20Osamu&rft.date=2000-10-01&rft.volume=108&rft.issue=10&rft.spage=931&rft.epage=935&rft.pages=931-935&rft.issn=0091-6765&rft.eissn=1552-9924&rft_id=info:doi/10.1289/ehp.00108931&rft_dat=%3Cgale_pubme%3EA68148361%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14554841&rft_id=info:pmid/11049811&rft_galeid=A68148361&rft_jstor_id=3435050&rfr_iscdi=true |