Genome Sequence and Comparative Microarray Analysis of Serotype M18 Group A Streptococcus Strains Associated with Acute Rheumatic Fever Outbreaks

Acute rheumatic fever (ARF), a sequelae of group A Streptococcus (GAS) infection, is the most common cause of preventable childhood heart disease worldwide. The molecular basis of ARF and the subsequent rheumatic heart disease are poorly understood. Serotype M18 GAS strains have been associated for...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-04, Vol.99 (7), p.4668-4673
Hauptverfasser:	Smoot, James C., Barbian, Kent D., Van Gompel, Jamie J., Smoot, Laura M., Chaussee, Michael S., Sylva, Gail L., Sturdevant, Daniel E., Ricklefs, Stacy M., Porcella, Stephen F., Parkins, Larye D., Beres, Stephen B., Campbell, David S., Smith, Todd M., Zhang, Qing, Kapur, Vivek, Daly, Judy A., Veasy, L. George, Musser, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease acute rheumatic fever Bacteriophages Base Sequence Biological Sciences Disease Outbreaks DNA DNA microarrays Genes Genetic transposition Genetic Variation Genome, Bacterial Genomes Genomics Humans Infections Molecular Sequence Data Oligonucleotide Array Sequence Analysis Open reading frames Operator regions rheumatic fever Rheumatic Fever - etiology Rheumatic Fever - microbiology Serotyping Streptococcus Streptococcus pyogenes - classification Streptococcus pyogenes - genetics Virulence - genetics
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