The role of tumor necrosis factor and nitric oxide in the acute cardiovascular response to endotoxin

This study was designed to examine the differential effects of tumor necrosis factor (TNF) and nitric oxide on the acute cardiovascular changes that occur in response to endotoxemia. Recent studies have suggested that some, if not all, of the cardiovascular effects of TNF are mediated through releas...

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Veröffentlicht in:	Annals of surgery 1996, Vol.223 (1), p.63-69
Hauptverfasser:	FAHEY, T. J, YOSHIOKA, T, SHIRES, G. T, FANTINI, G. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - analogs & derivatives Arginine - pharmacology Bacterial diseases Bacterial sepsis Biological and medical sciences Cardiovascular Diseases - physiopathology Endotoxins - administration & dosage Enzyme Inhibitors - pharmacology Hemodynamics - drug effects Human bacterial diseases Infectious diseases Medical sciences NG-Nitroarginine Methyl Ester Nitric Oxide - pharmacology Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Rats Rats, Sprague-Dawley Shock, Septic - physiopathology Toxemia - physiopathology Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - physiology
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