Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism

Chemotherapy doses are limited by toxicity to normal tissues. Intravenous glutamine protects liver cells from oxidant injury by increasing intracellular glutathione (GSH) content. The authors hypothesized that supplemental oral glutamine (GLN) would increase the therapeutic index of methotrexate (MT...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Annals of surgery 1995-04, Vol.221 (4), p.420-426
Hauptverfasser:	ROUSE, K, NWOKEDI, E, WOODLIFF, J. E, EPSTEIN, J, KLIMBERG, V. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Chemotherapy Drug Synergism Glutamine - therapeutic use Glutathione - metabolism Medical sciences Methotrexate - therapeutic use Pharmacology. Drug treatments Rats Rats, Inbred F344 Sarcoma, Experimental - drug therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!