Rectification of cystic fibrosis transmembrane conductance regulator chloride channel mediated by extracellular divalent cations

We report here distinct rectification of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel reconstituted in lipid bilayer membranes. Under the symmetrical ionic condition of 200 mM KCl (with 1 mM MgCl2 in cis intracellular and 0 MgCl2 in trans extracellular solutions, p...

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Veröffentlicht in:	Biophysical journal 1996-11, Vol.71 (5), p.2458-2466
Hauptverfasser:	Zhao, J., Zerhusen, B., Xie, J., Drumm, M.L., Davis, P.B., Ma, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Buffers Calcium - physiology Cations, Divalent Cell Line Chloride Channels - physiology Cystic Fibrosis Transmembrane Conductance Regulator - physiology Electric Conductivity Extracellular Space Humans Ion Channel Gating Lipid Bilayers Magnesium - physiology Membrane Potentials Microsomes Patch-Clamp Techniques Recombinant Proteins Surface Properties Transfection
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