Animal Antibiotic Use Has an Early but Important Impact on the Emergence of Antibiotic Resistance in Human Commensal Bacteria
Antibiotic use is known to promote the development of antibiotic resistance, but substantial controversy exists about the impact of agricultural antibiotic use (AAU) on the subsequent emergence of antibiotic-resistant bacteria among humans. AAU for animal growth promotion or for treatment or control...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2002-04, Vol.99 (9), p.6434-6439 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Smith, David L. Harris, Anthony D. Johnson, Judith A. Silbergeld, Ellen K. Morris, J. Glenn |
| description | Antibiotic use is known to promote the development of antibiotic resistance, but substantial controversy exists about the impact of agricultural antibiotic use (AAU) on the subsequent emergence of antibiotic-resistant bacteria among humans. AAU for animal growth promotion or for treatment or control of animal diseases generates reservoirs of antibiotic-resistant (AR) bacteria that contaminate animal food products. Mathematical models are an important tool for understanding the potential medical consequences of this increased exposure. We have developed a mathematical model to evaluate factors affecting the prevalence of human commensal AR bacteria that cause opportunistic infections (e.g., enterococci). Our analysis suggests that AAU hastens the appearance of AR bacteria in humans. Our model indicates that the greatest impact occurs very early in the emergence of resistance, when AR bacteria are rare, possibly below the detection limits of current surveillance methods. |
| doi_str_mv | 10.1073/pnas.082188899 |
| format | Article |
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Glenn</creatorcontrib><title>Animal Antibiotic Use Has an Early but Important Impact on the Emergence of Antibiotic Resistance in Human Commensal Bacteria</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Antibiotic use is known to promote the development of antibiotic resistance, but substantial controversy exists about the impact of agricultural antibiotic use (AAU) on the subsequent emergence of antibiotic-resistant bacteria among humans. AAU for animal growth promotion or for treatment or control of animal diseases generates reservoirs of antibiotic-resistant (AR) bacteria that contaminate animal food products. Mathematical models are an important tool for understanding the potential medical consequences of this increased exposure. 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| subjects | Agriculture Algorithms Animal Diseases - drug therapy Animal Diseases - microbiology Animals Animals, Domestic - microbiology Anti-Bacterial Agents - pharmacology Antibiotics Bacteria Bacteria - metabolism Bacterial Infections - microbiology Biological Sciences Commensals Disease transmission Drug resistance Drug Resistance, Microbial Drug Resistance, Multiple Evolution Health risk assessment Human populations Humans Livestock Mathematical models Models, Theoretical Population density |
| title | Animal Antibiotic Use Has an Early but Important Impact on the Emergence of Antibiotic Resistance in Human Commensal Bacteria |
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