Altered Sexual and Social Behaviors in Trp2 Mutant Mice

We have used gene targeting to generate mice with a homozygous deficiency in trp2, a cation channel expressed in the vomeronasal organ (VNO). Trp2 mutant animals reveal a striking reduction in the electrophysiological response to pheromones in the VNO, suggesting that trp2 plays a central role in me...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-04, Vol.99 (9), p.6376-6381
Hauptverfasser:	Leypold, Bradley G., Yu, C. Ron, Leinders-Zufall, Trese, Kim, Michelle M., Zufall, Frank, Axel, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggression Animal aggression Animal behavior Animals Biological Sciences cation channels Electrophysiology Female Female animals Gene Deletion Homozygote Human aggression Male Male animals Marking behavior Mating behavior Membrane Proteins - genetics Membrane Proteins - physiology Mice Mice, Inbred C57BL Mutation Neurology Pheromones Reproduction Rodents Sex Factors Sexual behavior Sexual Behavior, Animal trp2 gene TRPC Cation Channels Urine Vomeronasal Organ - physiology
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