Gene Expression Analysis Reveals Matrilysin as a Key Regulator of Pulmonary Fibrosis in Mice and Humans

Pulmonary fibrosis is a progressive and largely untreatable group of disorders that affects up to 100,000 people on any given day in the United States. To elucidate the molecular mechanisms that lead to end-stage human pulmonary fibrosis we analyzed samples from patients with histologically proven p...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-04, Vol.99 (9), p.6292-6297
Hauptverfasser:	Zuo, Fengrong, Kaminski, Naftali, Eugui, Elsie, Allard, John, Yakhini, Zohar, Ben-Dor, Amir, Lollini, Lance, Morris, David, Kim, Yong, DeLustro, Barbara, Sheppard, Dean, Pardo, Annie, Selman, Moises, Heller, Renu A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Biological Sciences Bleomycin - pharmacology Chemokines - metabolism Collagens Down-Regulation Female Fibroblasts Fibrosis Gene expression Genes Histology Humans Hydroxyproline - pharmacology Idiopathic pulmonary fibrosis Immunohistochemistry Lung - metabolism Lungs Male Matrix Metalloproteinase 7 - metabolism Matrix Metalloproteinase 7 - physiology Medical disorders Mice Mice, Knockout Muscle, Smooth - cytology Oligonucleotide Array Sequence Analysis Pneumonia Proteins Pulmonary alveoli Pulmonary fibrosis Pulmonary Fibrosis - metabolism RNA, Complementary - metabolism Smooth muscle Up-Regulation
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