Suppressor of Fused Represses Gli-Mediated Transcription by Recruiting the SAP18-mSin3 Corepressor Complex

The Suppressor of Fused [Su(fu)] protein plays a conserved role in the regulation of Gli transcription factors of the hedgehog (Hh) signaling pathway that controls cell fate and tissue patterning during development. In both Drosophila and mammals, Su(fu) represses Gli-mediated transcription, but the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-04, Vol.99 (8), p.5442-5447
Hauptverfasser:	Cheng, Steven Yan, Bishop, J. Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Blotting, Western Carrier Proteins Cell Nucleus - metabolism Cells Cellular biology Co repressor proteins Complementary DNA Cytoplasm - metabolism DNA DNA, Complementary - metabolism Dose-Response Relationship, Drug Drosophila Drosophila Proteins Gene Library Glutathione Transferase - metabolism HEK293 cells Histone Deacetylases - metabolism Histones Humans Oncogene Proteins - metabolism Plasmids Plasmids - metabolism Precipitin Tests Protein Binding Proteins Repression Repressor Proteins - metabolism Repressor Proteins - physiology RNA-Binding Proteins Saccharomyces cerevisiae Proteins SAP18 gene Suppressor of Fused protein Tissues Trans-Activators Transcription Factors - metabolism Transcription, Genetic Transfection Two-Hybrid System Techniques Yeasts Zinc Finger Protein GLI1
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