Genomewide-Linkage and Haplotype-Association Studies Map Intracranial Aneurysm to Chromosome 7q11

Rupture of intracranial aneurysms (IAs) causes subarachnoid hemorrhage, a devastating condition with high morbidity and mortality. Angiographic and autopsy studies show that IA is a common disorder, with a prevalence of 3%–6%. Although IA has a substantial genetic component, little attention has bee...

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Veröffentlicht in:	American journal of human genetics 2001-10, Vol.69 (4), p.804-819
Hauptverfasser:	Onda, Hideaki, Kasuya, Hidetoshi, Yoneyama, Taku, Takakura, Kintomo, Hori, Tomokatsu, Takeda, Jun, Nakajima, Toshiaki, Inoue, Ituro
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Alleles Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 7 - genetics Exons - genetics Female Gene Frequency - genetics Genetic Linkage - genetics Genome, Human Haplotypes - genetics Heterozygote Humans Intracranial Aneurysm - diagnostic imaging Intracranial Aneurysm - genetics Intracranial Aneurysm - pathology Introns - genetics Linkage Disequilibrium - genetics Male Matched-Pair Analysis Medical sciences Microsatellite Repeats - genetics Middle Aged Molecular Sequence Data Mutation, Missense - genetics Neurology Nuclear Family Physical Chromosome Mapping Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic - genetics Radiography Vascular diseases and vascular malformations of the nervous system
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