An estimated shape function for drift in a platelet-transport model
Prior work has shown that concentration profiles of platelets in flowing whole blood and of platelet-sized beads in flowing blood suspensions can include near-wall excesses. A model to describe this phenomenon was built about a single-component convective diffusion equation. To incorporate redistrib...
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| Veröffentlicht in: | Biophysical journal 1994-09, Vol.67 (3), p.1252-1259 |
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| container_title | Biophysical journal |
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| creator | Yeh, C. Calvez, A.C. Eckstein, E.C. |
| description | Prior work has shown that concentration profiles of platelets in flowing whole blood and of platelet-sized beads in flowing blood suspensions can include near-wall excesses. A model to describe this phenomenon was built about a single-component convective diffusion equation. To incorporate redistribution to preferred sites by shear flows of red cell suspensions, the model used a drift shape function (in addition to the commonly used augmented diffusion coefficient). This paper reports experiments that provide an average concentration profile from which the shape function for that model is calculated; the experiments and shape function are for the particular conditions of 40% hematocrit, platelet-sized latex beads (2.5 microns diameter), tube ID of 217 microns, and a wall shear rate of 555 s-1. Less precise estimates of the shape function obtained from data of previous studies indicate that the shape function is similar for the hematocrit of 15%. |
| doi_str_mv | 10.1016/S0006-3495(94)80595-8 |
| format | Article |
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Less precise estimates of the shape function obtained from data of previous studies indicate that the shape function is similar for the hematocrit of 15%.</description><subject>Biophysical Phenomena</subject><subject>Biophysics</subject><subject>Blood Platelets - physiology</subject><subject>Blood Platelets - ultrastructure</subject><subject>Cell Size - physiology</subject><subject>Erythrocytes - physiology</subject><subject>Hematocrit</subject><subject>Hemodynamics - physiology</subject><subject>Hemorheology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Models, Biological</subject><subject>Space life sciences</subject><issn>0006-3495</issn><issn>1542-0086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDFvFDEQhS0ECkeSnxDJFYJiYey1vXYDik6QIEVKEaitPe-YGO3Zi-2LxL-PkzudoKKa4r158-Yj5ILBBwZMfbwDANX1wsh3RrzXII3s9AuyYlLwDkCrl2R1tLwmb0r5BcC4BHZCTgbNmBGwIuvLSLHUsB0rTrTcjwtSv4uuhhSpT5lOOfhKQ6QjXeZmmrF2NY-xLClXuk0TzmfklR_ngueHeUp-fP3yfX3d3dxefVtf3nROKF67wesBpNz4Cbw2elBoJsc0OOGkUxupzIhiAwqY7yVgP4LhXmuUvZRccNWfkk_73GW32eLkMLYis11ya5__2DQG-68Sw739mR4s41wKzVvA20NATr937W27DcXhPI8R067YQRk-SGmaUe6NLqdSMvrjEQb2ib59pm-f0Foj7DN9q9vexd8Nj1sH3E3_vNexYXoImG1xAaPDKWR01U4p_OfCI-pFlOA</recordid><startdate>19940901</startdate><enddate>19940901</enddate><creator>Yeh, C.</creator><creator>Calvez, A.C.</creator><creator>Eckstein, E.C.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19940901</creationdate><title>An estimated shape function for drift in a platelet-transport model</title><author>Yeh, C. ; Calvez, A.C. ; Eckstein, E.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-7f87055bfd0f89876e9dc180c4c5c6b569ae4b0601f350e3a092f88e535524263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biophysical Phenomena</topic><topic>Biophysics</topic><topic>Blood Platelets - physiology</topic><topic>Blood Platelets - ultrastructure</topic><topic>Cell Size - physiology</topic><topic>Erythrocytes - physiology</topic><topic>Hematocrit</topic><topic>Hemodynamics - physiology</topic><topic>Hemorheology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Models, Biological</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeh, C.</creatorcontrib><creatorcontrib>Calvez, A.C.</creatorcontrib><creatorcontrib>Eckstein, E.C.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biophysical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeh, C.</au><au>Calvez, A.C.</au><au>Eckstein, E.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An estimated shape function for drift in a platelet-transport model</atitle><jtitle>Biophysical journal</jtitle><addtitle>Biophys J</addtitle><date>1994-09-01</date><risdate>1994</risdate><volume>67</volume><issue>3</issue><spage>1252</spage><epage>1259</epage><pages>1252-1259</pages><issn>0006-3495</issn><eissn>1542-0086</eissn><abstract>Prior work has shown that concentration profiles of platelets in flowing whole blood and of platelet-sized beads in flowing blood suspensions can include near-wall excesses. 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| ispartof | Biophysical journal, 1994-09, Vol.67 (3), p.1252-1259 |
| issn | 0006-3495 1542-0086 |
| language | eng |
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| source | MEDLINE; Cell Press Free Archives; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biophysical Phenomena Biophysics Blood Platelets - physiology Blood Platelets - ultrastructure Cell Size - physiology Erythrocytes - physiology Hematocrit Hemodynamics - physiology Hemorheology Humans In Vitro Techniques Models, Biological Space life sciences |
| title | An estimated shape function for drift in a platelet-transport model |
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