A proximal tissue-specific module and a distal negative regulatory module control apolipoprotein(a) gene transcription

The apo(a) [apolipoprotein(a)] gene is responsible for variations in plasma lipoprotein(a), high levels of which are a risk factor for atherosclerosis and myocardial infarction. The apo(a) promoter stimulates the expression of reporter genes in HepG2 cells, but not in HeLa cells. In the present stud...

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Veröffentlicht in:	Biochemical journal 2004-04, Vol.379 (Pt 1), p.151-159
Hauptverfasser:	Negi, Sarita, Singh, Saurabh K, Pati, Nirupma, Handa, Vikas, Chauhan, Ruchi, Pati, Uttam
Format:	Artikel
Sprache:	eng
Schlagworte:	Apolipoproteins A - biosynthesis Apolipoproteins A - genetics Carcinoma, Hepatocellular - pathology Cardiovascular Diseases - genetics Cell Line, Tumor - metabolism Gene Expression Regulation - genetics Gene Expression Regulation, Neoplastic Genes, Reporter Genetic Predisposition to Disease HeLa Cells - metabolism Humans Liver Neoplasms - pathology Neoplasm Proteins - physiology Organ Specificity Promoter Regions, Genetic - genetics Protein Binding Regulatory Sequences, Nucleic Acid Repetitive Sequences, Nucleic Acid Repressor Proteins - metabolism Risk Factors Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation Transfection
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