The TRAP/Mediator Coactivator Complex Interacts Directly with Estrogen Receptors α and β through the TRAP220 Subunit and Directly Enhances Estrogen Receptor Function in vitro

Target gene activation by nuclear hormone receptors, including estrogen receptors (ERs), is thought to be mediated by a variety of interacting cofactors. Here we identify a number of nuclear extract-derived proteins that interact with immobilized ER ligand binding domains in a 17β-estradiol-dependen...

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