Rapid agonist-evoked coupling of type II Ins(1,4,5)P3 receptor with human transient receptor potential (hTRPC1) channels in human platelets

Depletion of intracellular Ca2+ stores results in the activation of SMCE (store-mediated Ca2+ entry) in many cells. The mechanism of activation of SMCE is poorly understood. In human platelets, a secretion-like coupling model may be involved. This proposes that store depletion results in trafficking...

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Veröffentlicht in:	Biochemical journal 2003-11, Vol.375 (Pt 3), p.697-704
Hauptverfasser:	Brownlow, Sharon L, Sage, Stewart O
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets - drug effects Blood Platelets - metabolism Calcium - metabolism Calcium Channels - metabolism Cations, Divalent - metabolism Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Humans Indoles - pharmacology Inositol 1,4,5-Trisphosphate Receptors Manganese - metabolism Protein Kinase C - antagonists & inhibitors Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - metabolism Thrombin - pharmacology Time Factors TRPC Cation Channels
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