Identification of a novel Na+- and Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat

The endogenous opioid peptides enkephalins, dynorphins and endorphins consist of five or more amino acids. These peptides participate in a multitude of biological functions in mammalian cells by interacting with different subtypes of opiate receptors located on the plasma membrane and in the nucleus...

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Veröffentlicht in:	Biochemical journal 2003-10, Vol.375 (Pt 1), p.17-22
Hauptverfasser:	Hu, Huankai, Miyauchi, Seiji, Bridges, Christy C, Smith, Sylvia B, Ganapathy, Vadivel
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport, Active Cell Line Chlorides - pharmacology Gene Products, tat - metabolism HIV-1 Humans Kinetics Membrane Transport Proteins - metabolism Oligopeptides - metabolism Opioid Peptides - metabolism Pigment Epithelium of Eye - drug effects Pigment Epithelium of Eye - metabolism Sodium - pharmacology Substrate Specificity tat Gene Products, Human Immunodeficiency Virus
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