Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues

Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low i...

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Veröffentlicht in:	Biochemical journal 2003-03, Vol.370 (Pt 2), p.397-402
Hauptverfasser:	Schomburg, Lutz, Schweizer, Ulrich, Holtmann, Bettina, Flohé, Leopold, Sendtner, Michael, Köhrle, Josef
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport - genetics Gene Deletion Mice Mice, Transgenic Proteins - genetics Proteins - metabolism Selenium - metabolism Selenoprotein P Selenoproteins
Online-Zugang:	Volltext
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