Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues

Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues

Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low i...

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Veröffentlicht in:Biochemical journal 2003-03, Vol.370 (Pt 2), p.397-402
Hauptverfasser: Schomburg, Lutz, Schweizer, Ulrich, Holtmann, Bettina, Flohé, Leopold, Sendtner, Michael, Köhrle, Josef
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological Transport - genetics
Gene Deletion
Mice
Mice, Transgenic
Proteins - genetics
Proteins - metabolism
Selenium - metabolism
Selenoprotein P
Selenoproteins
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container_end_page 402
container_issue Pt 2
container_start_page 397
container_title Biochemical journal
container_volume 370
creator Schomburg, Lutz
Schweizer, Ulrich
Holtmann, Bettina
Flohé, Leopold
Sendtner, Michael
Köhrle, Josef
description Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues.
doi_str_mv 10.1042/bj20021853
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subjects Animals
Biological Transport - genetics
Gene Deletion
Mice
Mice, Transgenic
Proteins - genetics
Proteins - metabolism
Selenium - metabolism
Selenoprotein P
Selenoproteins
title Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues
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