Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice

Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that controls expression of genes involved in lipid metabolism and is activated by fatty acids and hypolipidaemic fibrates. Fibrates induce the hepatic expression of murine multidrug resistance 2 ( Mdr2 ), encoding th...

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Veröffentlicht in:	Biochemical journal 2003-02, Vol.369 (Pt 3), p.539-547
Hauptverfasser:	Kok, Tineke, Bloks, Vincent W, Wolters, Henk, Havinga, Rick, Jansen, Peter L M, Staels, Bart, Kuipers, Folkert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Subfamily B - drug effects ATP Binding Cassette Transporter, Subfamily B - genetics ATP Binding Cassette Transporter, Subfamily B - metabolism ATP Binding Cassette Transporter, Subfamily B, Member 11 ATP Binding Cassette Transporter, Subfamily G, Member 5 ATP Binding Cassette Transporter, Subfamily G, Member 8 ATP-Binding Cassette Sub-Family B Member 4 ATP-Binding Cassette Transporters - drug effects ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Bile - chemistry Bile - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cells, Cultured Clofibric Acid - analogs & derivatives Clofibric Acid - pharmacology Fibric Acids Hepatocytes - physiology Lipid Metabolism Lipoproteins - genetics Lipoproteins - metabolism Liver - drug effects Liver - metabolism Liver - pathology Male Membrane Transport Proteins Mice Mice, Mutant Strains Organ Size - drug effects Organic Anion Transporters, Sodium-Dependent Organic Anion Transporters, Sodium-Independent - genetics Organic Anion Transporters, Sodium-Independent - metabolism Peroxisome Proliferators - pharmacology Pyrimidines - pharmacology Receptors, Cytoplasmic and Nuclear - drug effects Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Symporters Taurochenodeoxycholic Acid - administration & dosage Taurochenodeoxycholic Acid - pharmacology Transcription Factors - drug effects Transcription Factors - genetics Transcription Factors - metabolism
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