Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation
The Wnt signal transduction pathway regulates morphogenesis and mitogenesis of cells in multicellular organisms. A major downstream consequence of Wnt-1 signalling is the activation of beta-catenin/T-cell factor (TCF)-mediated transcription. We compared Wnt-1-transformed murine mammary epithelial ce...
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| Veröffentlicht in: | Biochemical journal 2002-11, Vol.367 (Pt 3), p.723-728 |
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| container_issue | Pt 3 |
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| container_title | Biochemical journal |
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| creator | Chtarbova, Slava Nimmrich, Inko Erdmann, Silke Herter, Peter Renner, Matthias Kitajewski, Jan Müller, Oliver |
| description | The Wnt signal transduction pathway regulates morphogenesis and mitogenesis of cells in multicellular organisms. A major downstream consequence of Wnt-1 signalling is the activation of beta-catenin/T-cell factor (TCF)-mediated transcription. We compared Wnt-1-transformed murine mammary epithelial cells with control cells by subtractive hybridization. We found the two genes Nr4a1 and Herpud1 to be overexpressed in Wnt-1-transformed cells. Remarkably, the transcription levels of the two homologous human genes NR4A1 and HERPUD1 are neither activated in cells with activated beta-catenin/TCF-mediated transcription nor can be induced by beta-catenin transfection. These results indicate different regulation mechanisms of the two genes in murine and human cells. |
| doi_str_mv | 10.1042/BJ20020699 |
| format | Article |
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A major downstream consequence of Wnt-1 signalling is the activation of beta-catenin/T-cell factor (TCF)-mediated transcription. We compared Wnt-1-transformed murine mammary epithelial cells with control cells by subtractive hybridization. We found the two genes Nr4a1 and Herpud1 to be overexpressed in Wnt-1-transformed cells. Remarkably, the transcription levels of the two homologous human genes NR4A1 and HERPUD1 are neither activated in cells with activated beta-catenin/TCF-mediated transcription nor can be induced by beta-catenin transfection. 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A major downstream consequence of Wnt-1 signalling is the activation of beta-catenin/T-cell factor (TCF)-mediated transcription. We compared Wnt-1-transformed murine mammary epithelial cells with control cells by subtractive hybridization. We found the two genes Nr4a1 and Herpud1 to be overexpressed in Wnt-1-transformed cells. Remarkably, the transcription levels of the two homologous human genes NR4A1 and HERPUD1 are neither activated in cells with activated beta-catenin/TCF-mediated transcription nor can be induced by beta-catenin transfection. These results indicate different regulation mechanisms of the two genes in murine and human cells.</description><subject>Animals</subject><subject>beta Catenin</subject><subject>Blotting, Northern</subject><subject>Cytoskeletal Proteins - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Mice</subject><subject>Proto-Oncogene Proteins - physiology</subject><subject>Signal Transduction</subject><subject>Trans-Activators - metabolism</subject><subject>Transcription, Genetic</subject><subject>Transfection</subject><subject>Up-Regulation - physiology</subject><subject>Wnt Proteins</subject><subject>Wnt1 Protein</subject><subject>Zebrafish Proteins</subject><issn>0264-6021</issn><issn>1470-8728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQhS0EoreFDT8AecWiIuBn4myQaEUpVYENiKXlOJN7XSV28KNSV_x1XHp5rboZj8afzxz5IPSMkleUCPb65IIRwkjb9w_QhoqONKpj6iHaENaKpiWMHqDDlK4IoYII8hgdUEYl5327QT8-lug84E9RGIqNH_E5xLWMtY-Ay9pE2JbZZBjxcIO_-dzQl3goGecd4F1Ywhy2oSS8K4vxeAse0q-Xzo-wQi0-4ymGBQ-QTWOrkHceG5vdtcku-Cfo0WTmBE_35xH6evbuy-l5c_n5_YfTt5eNFUTWpcxKMQ5c9tJYIagyAnpJW2XJZCeQCiY1MNtzSYwhcuhknYPsgXLgEhQ_Qm_udNcyLDDa6iuaWa_RLSbe6GCc_v_Gu53ehmtNGWM9vxV4sReI4XuBlPXikoV5Nh7qB-iOScaIuh-kqpOSUl7B4zvQxpBShOmPG0r0bbB6uPodbIWf_-v_L7pPkv8EiEqfUg</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Chtarbova, Slava</creator><creator>Nimmrich, Inko</creator><creator>Erdmann, Silke</creator><creator>Herter, Peter</creator><creator>Renner, Matthias</creator><creator>Kitajewski, Jan</creator><creator>Müller, Oliver</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20021101</creationdate><title>Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation</title><author>Chtarbova, Slava ; Nimmrich, Inko ; Erdmann, Silke ; Herter, Peter ; Renner, Matthias ; Kitajewski, Jan ; Müller, Oliver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-12c54db3595ac4418a4e95168c0fcfe58ef8b2c9350aa05b750fce59e13e35e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>beta Catenin</topic><topic>Blotting, Northern</topic><topic>Cytoskeletal Proteins - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Mice</topic><topic>Proto-Oncogene Proteins - physiology</topic><topic>Signal Transduction</topic><topic>Trans-Activators - metabolism</topic><topic>Transcription, Genetic</topic><topic>Transfection</topic><topic>Up-Regulation - physiology</topic><topic>Wnt Proteins</topic><topic>Wnt1 Protein</topic><topic>Zebrafish Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chtarbova, Slava</creatorcontrib><creatorcontrib>Nimmrich, Inko</creatorcontrib><creatorcontrib>Erdmann, Silke</creatorcontrib><creatorcontrib>Herter, Peter</creatorcontrib><creatorcontrib>Renner, Matthias</creatorcontrib><creatorcontrib>Kitajewski, Jan</creatorcontrib><creatorcontrib>Müller, Oliver</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chtarbova, Slava</au><au>Nimmrich, Inko</au><au>Erdmann, Silke</au><au>Herter, Peter</au><au>Renner, Matthias</au><au>Kitajewski, Jan</au><au>Müller, Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation</atitle><jtitle>Biochemical journal</jtitle><addtitle>Biochem J</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>367</volume><issue>Pt 3</issue><spage>723</spage><epage>728</epage><pages>723-728</pages><issn>0264-6021</issn><eissn>1470-8728</eissn><abstract>The Wnt signal transduction pathway regulates morphogenesis and mitogenesis of cells in multicellular organisms. 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| ispartof | Biochemical journal, 2002-11, Vol.367 (Pt 3), p.723-728 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals beta Catenin Blotting, Northern Cytoskeletal Proteins - metabolism Humans Immunohistochemistry Mice Proto-Oncogene Proteins - physiology Signal Transduction Trans-Activators - metabolism Transcription, Genetic Transfection Up-Regulation - physiology Wnt Proteins Wnt1 Protein Zebrafish Proteins |
| title | Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation |
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