Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors

Sphingosine 1-phosphate (SPP) is a bioactive lipid that exerts multiple biological effects in a large variety of cell types, acting as either an intracellular messenger or an extracellular ligand coupled to Edg-family receptors (where Edg stands for endothelial differentiation gene). Here we report...

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Veröffentlicht in:	Biochemical journal 2002-03, Vol.362 (Pt 2), p.349-357
Hauptverfasser:	Meacci, Elisabetta, Cencetti, Francesca, Formigli, Lucia, Squecco, Roberta, Donati, Chiara, Tiribilli, Bruno, Quercioli, Franco, Zecchi Orlandini, Sandra, Francini, Fabio, Bruni, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology Cells, Cultured DNA-Binding Proteins - metabolism Egtazic Acid - pharmacology Enzyme Inhibitors - pharmacology I-kappa B Proteins Kinetics Lysophospholipids Muscle, Skeletal - drug effects Muscle, Skeletal - physiology NF-KappaB Inhibitor alpha Pertussis Toxin Protein Kinase C - metabolism Receptors, Cell Surface - metabolism Receptors, G-Protein-Coupled Receptors, Lysophospholipid Sphingosine - analogs & derivatives Sphingosine - pharmacology Virulence Factors, Bordetella - pharmacology
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