Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues

Multidrug resistance protein 4 (MRP4/ABCC4) is a member of the MRP subfamily, which in turn is a member of the superfamily of ATP-binding-cassette (ABC) transporters. Within the MRP subfamily, ABCC4,ABCC5 (MRP5), ABCC11 (MRP8) and ABCC12 (MRP9) have similar predicted membrane topologies. All lack th...

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Veröffentlicht in:	Biochemical journal 2002-02, Vol.361 (Pt 3), p.497-503
Hauptverfasser:	Lai, Liqi, Tan, Theresa M C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Biological Transport Blotting, Western Cell Line Cloning, Molecular Cyclic AMP - metabolism Dogs Glutathione - chemistry Glutathione - metabolism Glutathione - physiology Humans Immunoblotting Microscopy, Fluorescence Multidrug Resistance-Associated Proteins Protein Structure, Tertiary Purines - chemistry Ribosomal Proteins - chemistry Transfection Tumor Cells, Cultured
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