Colony-stimulating factor-1 (CSF-1) receptor-mediated macrophage differentiation in myeloid cells: a role for tyrosine 559-dependent protein phosphatase 2A (PP2A) activity

M1 myeloid cells transfected with the wild-type (WT) colony-stimulating factor-1 (CSF-1) receptor (CSF-1R; M1/WT cells) undergo CSF-1-dependent macrophage differentiation. By mutation studies, we have provided prior evidence that tyrosine 559 in the CSF-1R cytoplasmic domain governs the Src-dependen...

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Veröffentlicht in:	Biochemical journal 2001-09, Vol.358 (Pt 2), p.431-436
Hauptverfasser:	McMahon, K A, Wilson, N J, Marks, D C, Beecroft, T L, Whitty, G A, Hamilton, J A, Csar, X F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell Line Enzyme Inhibitors - pharmacology Macrophages - cytology Macrophages - physiology Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Mutation Myeloid Cells - cytology Myeloid Cells - drug effects Okadaic Acid - pharmacology Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - metabolism Phosphorylation Phosphotyrosine - metabolism Protein Phosphatase 2 Receptor, Macrophage Colony-Stimulating Factor - chemistry Receptor, Macrophage Colony-Stimulating Factor - genetics Receptor, Macrophage Colony-Stimulating Factor - physiology Signal Transduction
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