Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells

A well-established protocol to increase the intracellular content of ascorbic acid was used to investigate the effects of the vitamin on DNA single-strand breakage and toxicity mediated by authentic peroxynitrite (ONOO(-)) in U937 cells. This protocol involved exposure for 60 min to 100 microM dehyd...

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Veröffentlicht in:	Biochemical journal 2001-06, Vol.356 (Pt 2), p.509-513
Hauptverfasser:	Guidarelli, A, De Sanctis, R, Cellini, B, Fiorani, M, Dachà, M, Cantoni, O
Format:	Artikel
Sprache:	eng
Schlagworte:	Ascorbic Acid - metabolism Ascorbic Acid - toxicity Dehydroascorbic Acid - metabolism Dehydroascorbic Acid - pharmacology DNA Damage Ferricyanides - metabolism Free Radical Scavengers - pharmacology Humans Iron Chelating Agents - pharmacology Nitrates - toxicity Oxidation-Reduction U937 Cells
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