Differential effects of oncostatin M and leukaemia inhibitory factor expression in astrocytoma cells

The effects of the production of two closely related cytokines, oncostatin M (OSM) and leukaemia inhibitory factor (LIF), by astrocytoma cells were investigated using the stable cell line human U373-MG, which expressed and secreted both biologically active polypeptides. The expression of LIF by thes...

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Veröffentlicht in:	Biochemical journal 2001-04, Vol.355 (Pt 2), p.307-314
Hauptverfasser:	Kasza, A, Rogowski, K, Kilarski, W, Sobota, R, Bernas, T, Dobrucki, J, Travis, J, Koj, A, Bugno, M, Kordula, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - metabolism Astrocytoma - metabolism Astrocytoma - pathology Base Sequence Cytokine Receptor gp130 DNA Primers Endoplasmic Reticulum - metabolism Gene Expression Regulation, Neoplastic - physiology Growth Inhibitors - metabolism Growth Inhibitors - physiology Humans Interleukin-6 Janus Kinase 1 Leukemia Inhibitory Factor Leukemia Inhibitory Factor Receptor alpha Subunit Lymphokines - metabolism Lymphokines - physiology Membrane Glycoproteins - metabolism Oncostatin M Peptides - metabolism Peptides - physiology Protein-Tyrosine Kinases - metabolism Receptors, Cytokine - metabolism Receptors, OSM-LIF Transcription Factors - metabolism Tumor Cells, Cultured
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