Characterization of the Mycobacterium tuberculosis H37Rv alkyl hydroperoxidase AhpC points to the importance of ionic interactions in oligomerization and activity

An alkyl hydroperoxidase (AhpC) has been found frequently to be overexpressed in isoniazid-resistant strains of Mycobacterium tuberculosis. These strains have an inactivated katG gene encoding a catalase peroxidase, which might render mycobacteria susceptible to the toxic peroxide radicals, thus lea...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical journal 2001-02, Vol.354 (Pt 1), p.209-215
Hauptverfasser:	Chauhan, R, Mande, S C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopolymers Chromatography, Gel Chromatography, Ion Exchange Cloning, Molecular Ions Models, Molecular Mycobacterium tuberculosis - enzymology Peroxidases - chemistry Peroxidases - isolation & purification Peroxidases - metabolism Peroxiredoxins Protein Conformation Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!