Fusion of the tissue factor extracellular domain to a tumour stroma specific single-chain fragment variable antibody results in an antigen-specific coagulation-promoting molecule

Solid tumours growing beyond a size of 1-2 mm in diameter induce supporting connective tissue structures, the tumour stroma, comprising activated fibroblasts and newly formed blood vessels, embedded in an extracellular matrix. The selective destruction of this tissue or the inhibition of its functio...

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Veröffentlicht in:	Biochemical journal 2000-08, Vol.349 Pt 3 (3), p.805-812
Hauptverfasser:	Rippmann, J F, Pfizenmaier, K, Mattes, R, Rettig, W J, Moosmayer, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - immunology Antibodies - metabolism Antigen-Antibody Reactions Base Sequence DNA Primers Neoplasms - immunology Thromboplastin - chemistry Thromboplastin - metabolism
Online-Zugang:	Volltext
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