Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase

We recently identified a novel adaptor protein, termed dual adaptor for phosphotyrosine and 3-phosphoinositides (DAPP1), that possesses a Src homology (SH2) domain and a pleckstrin homology (PH) domain. DAPP1 exhibits a high-affinity interaction with PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2), which bind...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical journal 2000-07, Vol.349 (Pt 2), p.605-610
Hauptverfasser:	Dowler, S, Montalvo, L, Cantrell, D, Morrice, N, Alessi, D R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Blood Proteins - metabolism Cells, Cultured Enzyme Inhibitors - pharmacology Escherichia coli Fatty Acids - metabolism Humans Lipoproteins Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - biosynthesis Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositols - metabolism Phosphorylation - drug effects Phosphotyrosine - metabolism src-Family Kinases - antagonists & inhibitors src-Family Kinases - biosynthesis src-Family Kinases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!