Oxidation of ubiquinol by peroxynitrite: implications for protection of mitochondria against nitrosative damage

A major pathway of nitric oxide utilization in mitochondria is its conversion to peroxynitrite, a species involved in biomolecule damage via oxidation, hydroxylation and nitration reactions. In the present study the potential role of mitochondrial ubiquinol in protecting against peroxynitrite-mediat...

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Veröffentlicht in:	Biochemical journal 2000-07, Vol.349 (Pt 1), p.35-42
Hauptverfasser:	Schöpfer, F, Riobó, N, Carreras, M C, Alvarez, B, Radi, R, Boveris, A, Cadenas, E, Poderoso, J J
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - metabolism Animals Coenzymes Dose-Response Relationship, Drug Electron Spin Resonance Spectroscopy Immunoblotting Kinetics Mitochondria - metabolism Mitochondria, Liver - metabolism Models, Chemical Nitrates - metabolism Nitrates - pharmacology Oxidation-Reduction Oxidative Stress Oxygen Oxygen Consumption Protein Binding Rats Spectrophotometry Time Factors Tyrosine - metabolism Ubiquinone - analogs & derivatives Ubiquinone - metabolism
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