Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells

Pancreatic-duodenal homoeobox factor-1 (PDX1) is a homoeodomain transcription factor that plays an important role in linking glucose metabolism in pancreatic beta cells to the regulation of insulin gene transcription. Our previous results indicated that glucose activates PDX1 DNA-binding activity an...

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Veröffentlicht in:	Biochemical journal 1999-12, Vol.344 Pt 3 (3), p.813-818
Hauptverfasser:	Wu, H, MacFarlane, W M, Tadayyon, M, Arch, J R, James, R F, Docherty, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Line Chromones - pharmacology DNA-Binding Proteins - metabolism Glucose - pharmacology Homeodomain Proteins - metabolism Humans Imidazoles - pharmacology Insulin - pharmacology Islets of Langerhans - drug effects Islets of Langerhans - metabolism Mitogen-Activated Protein Kinases Morpholines - pharmacology Oligodeoxyribonucleotides - metabolism p38 Mitogen-Activated Protein Kinases Pancreatic-duodenal homeobox factor 1 Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Promoter Regions, Genetic Pyridines - pharmacology stress-activated protein kinase 2 Trans-Activators - metabolism Transfection
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