Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose

The glycation of proteins by glucose has been linked to the development of diabetic complications and other diseases. Early glycation is thought to involve the reaction of glucose with N-terminal and lysyl side chain amino groups to form Schiff's base and fructosamine adducts. The formation of...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical journal 1999-11, Vol.344 Pt 1 (1), p.109-116
Hauptverfasser:	Thornalley, P J, Langborg, A, Minhas, H S
Format:	Artikel
Sprache:	eng
Schlagworte:	Deoxyglucose - analogs & derivatives Deoxyglucose - biosynthesis Fructosamine - metabolism Glucose - metabolism Glycation End Products, Advanced - metabolism Glycosylation Glyoxal - metabolism Humans In Vitro Techniques Lysine - analogs & derivatives Lysine - metabolism Proteins - metabolism Pyruvaldehyde - metabolism Schiff Bases - metabolism Serum Albumin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!