Peptidase activity of beta-lactamases

Although beta-lactamases have generally been considered as being devoid of peptidase activity, a low but significant hydrolysis of various N-acylated dipeptides was observed with representatives of each class of beta-lactamases. The kcat/Km values were below 0.1 M(-1). s(-1), but the enzyme rate enh...

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Veröffentlicht in:	Biochemical journal 1999-07, Vol.341 ( Pt 2) (2), p.409-413
Hauptverfasser:	Rhazi, N, Galleni, M, Page, M I, Frère, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus - enzymology beta-Lactamases - chemistry beta-Lactamases - metabolism Carboxypeptidases - chemistry Carboxypeptidases - metabolism Catalysis Catalytic mechanism DD-peptidases Hydrolysis kinetics Life sciences Microbiologie Microbiology Sciences du vivant Substrate Specificity
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